Epilepsy is a chronic neurological disease characterized by an enduring propensity for
generation of seizures. The pathogenic processes of seizure generation and recurrence are …

Prevention of epilepsy is a great unmet need. Acute central nervous system (CNS) insults
such as traumatic brain injury (TBI), cerebrovascular accidents (CVA), and CNS infections …

Epilepsy is a chronic and recurrent disease of the central nervous system, with a complex
pathology. Recent studies have demonstrated that the activation of glial cells serve an …

Febrile infection‐related epilepsy syndrome (FIRES) is a rare catastrophic epileptic
encephalopathy that presents suddenly in otherwise normal children and young adults …

Inhibiting microglia proliferation after spinal cord injury improves recovery in mice and
nonhuman primates - PMC Back to Top Skip to main content NIH NLM Logo Access keys …

Background: The pathophysiology underlying altered blood-cerebrospinal fluid barrier
(BCSFB) function in Alzheimer's disease (AD) is unknown but may relate to endothelial cell …

Abstract Lafora disease (LD; OMIM# 254780) is a rare form of progressive myoclonus
epilepsy (prevalence< 1: 1,000,000) characterized by the accumulation of insoluble deposits …

Epilepsy is the most common neurological disorder, affecting nearly 50 million people
worldwide. The condition can be manifested either due to genetic predisposition or acquired …

Lafora disease (LD) is a rare, fatal form of progressive myoclonus epilepsy. The molecular
basis of this devastating disease is still poorly understood, and no treatment is available yet …

Epileptic seizures are characterized by synchronized discharges of neurons, leading to the
activation of inflammatory responses that in turn contributes to seizure progression …