WNT signaling in bone homeostasis and disease: from human mutations to treatments

R Baron, M Kneissel - Nature medicine, 2013 - nature.com
Low bone mass and strength lead to fragility fractures, for example, in elderly individuals
affected by osteoporosis or children with osteogenesis imperfecta. A decade ago, rare …

The effects of novel and newly approved antipsychotics on serum prolactin levels: a comprehensive review

J Peuskens, L Pani, J Detraux, M De Hert - CNS drugs, 2014 - Springer
Since the 1970s, clinicians have increasingly become more familiar with hyperprolactinemia
(HPRL) as a common adverse effect of antipsychotic medication, which remains the …

Benzodiazepine use in the United States

M Olfson, M King, M Schoenbaum - JAMA psychiatry, 2015 - jamanetwork.com
Importance Although concern exists regarding the rate of benzodiazepine use, especially
long-term use by older adults, little information is available concerning patterns of …

[HTML][HTML] Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care

M De Hert, CU Correll, J Bobes… - World …, 2011 - ncbi.nlm.nih.gov
The lifespan of people with severe mental illness (SMI) is shorter compared to the general
population. This excess mortality is mainly due to physical illness. We report prevalence …

[HTML][HTML] Physical illness in patients with severe mental disorders. II. Barriers to care, monitoring and treatment guidelines, plus recommendations at the system and …

M De Hert, DAN Cohen, J Bobes… - World …, 2011 - ncbi.nlm.nih.gov
Physical disorders are, compared to the general population, more prevalent in people with
severe mental illness (SMI). Although this excess morbidity and mortality is largely due to …

Benzodiazepines, Z-drugs and the risk of hip fracture: A systematic review and meta-analysis

K Donnelly, R Bracchi, J Hewitt, PA Routledge… - PloS one, 2017 - journals.plos.org
Background Hip fractures in the older person lead to an increased risk of mortality, poorer
quality of life and increased morbidity. Benzodiazepine (BNZ) use is associated with …

The complex interplay of depression and falls in older adults: a clinical review

A Iaboni, AJ Flint - The American Journal of Geriatric Psychiatry, 2013 - Elsevier
Depression and falls have a significant bidirectional relationship. Excessive fear of falling,
which is frequently associated with depression, also increases the risk of falls. Both …

Hip fracture epidemiological trends, outcomes, and risk factors, 1970–2009

R Marks - International journal of general medicine, 2010 - Taylor & Francis
Hip fractures–which commonly lead to premature death, high rates of morbidity, or reduced
life quality–have been the target of a voluminous amount of research for many years. But …

Update on bone anabolics in osteoporosis treatment: rationale, current status, and perspectives

R Baron, E Hesse - The Journal of Clinical Endocrinology & …, 2012 - academic.oup.com
Osteoporosis is defined as low bone mineral density associated with skeletal fractures
secondary to minimal or no trauma, most often involving the spine, the hip, and the forearm …

Atypical antipsychotic use in patients with dementia: managing safety concerns

M Steinberg, CG Lyketsos - American Journal of Psychiatry, 2012 - Am Psychiatric Assoc
Neuropsychiatric symptoms such as agitation and delusions occur commonly in elderly
patients with dementia and often cause significant distress. Data on treatment efficacy are …