Acute myeloid leukemia (AML) is a malignant disorder of the bone marrow which is
characterized by the clonal expansion and differentiation arrest of myeloid progenitor cells …

Fanconi anaemia (FA) is a genetic disorder that is characterized by bone marrow failure
(BMF), developmental abnormalities and predisposition to cancer. Together with other …

The National Cancer Institute Inherited Bone Marrow Failure Syndromes Cohort enrolls
patients with the four major syndromes: Fanconi anemia, dyskeratosis congenita, Diamond …

Haematopoietic stem cells (HSCs) are responsible for the lifelong production of blood cells.
The accumulation of DNA damage in HSCs is a hallmark of ageing and is probably a major …

Fanconi anemia (FA) patients experience chromosome instability, yielding hematopoietic
stem/progenitor cell (HSPC) exhaustion and predisposition to poor-prognosis myeloid …

Fanconi anemia (FA) is a DNA repair syndrome generated by mutations in any of the 22 FA
genes discovered to date,. Mutations in FANCA account for more than 60% of FA cases …

Advances in genomic research and risk-directed therapy have led to improvements in the
long-term survival and quality of life outcomes of patients with childhood acute lymphoblastic …

Cancer genetics is increasingly becoming integrated into the practice of modern medical
oncology. The ability to distinguish a growing proportion of the 5% to 10% of all cancers that …

Fanconi anemia (FA) is a genetically and phenotypically heterogeneous recessive disorder
characterized by diverse congenital malformations, progressive pancytopenia, and …

Haematopoietic stem cells (HSCs) regenerate blood cells throughout the lifespan of an
organism. With age, the functional quality of HSCs declines, partly owing to the …