The accessibility of new genomic resources, high‐throughput molecular technologies and
analytical approaches such as genome scans have made finding genes contributing to …

In an aging society, research involving neurodegenerative disorders is of paramount
importance. Over the past few years, research on Alzheimer's and Parkinson's diseases has …

Research in the fruit fly Drosophila melanogaster has led to insights in neural development,
axon guidance, ion channel function, synaptic transmission, learning and memory, diurnal …

Existing transgenic RNA interference (RNAi) methods greatly facilitate functional genome
studies via controlled silencing of targeted mRNA in Drosophila. Although the RNAi …

Animals select their optimal environmental temperature, even when faced with alternatives
that differ only slightly. This behavior is critical as small differences in temperature of only …

Synaptic dysfunction is recognized as an early step in the pathophysiology of parkinsonism.
Several genetic mutations affecting the integrity of synaptic proteins cause or increase the …

Chemical synapses are specialist points of contact between two neurons, where information
transfer takes place. Communication occurs through the release of neurotransmitter …

Manipulating gene function cell type-specifically is a common experimental goal in
Drosophila research and has been central to studies of neural development, circuit …

Recent evidence links dysfunctional lipid metabolism to the pathogenesis of Parkinson's
disease, but the mechanisms are not resolved. Here, we generated a new Drosophila knock …

Neurogenesis is initiated by the transient expression of the highly conserved proneural
proteins, bHLH transcriptional regulators. Here, we discover a conserved post-translational …