Long COVID or post-COVID-19 condition: past, present and future research directions

C Fernández-de-Las-Peñas, AV Raveendran… - Microorganisms, 2023 - mdpi.com
The presence of symptoms after an acute SARS-CoV-2 infection (long-COVID) has become
a worldwide healthcare emergency but remains underestimated and undertreated due to a …

Peripheral blood omics and other multiplex-based systems in pulmonary and critical care medicine

J Balnis, EJM Lauria, R Yucel, HA Singer… - American Journal of …, 2023 - atsjournals.org
Over the last years, the use of peripheral blood–derived big datasets in combination with
machine learning technology has accelerated the understanding, prediction, and …

Blood DNA methylation in post-acute sequelae of COVID-19 (PASC): a prospective cohort study

J Balnis, A Madrid, LA Drake, R Vancavage, A Tiwari… - Ebiomedicine, 2024 - thelancet.com
Background DNA methylation integrates environmental signals with transcriptional
programs. COVID-19 infection induces changes in the host methylome. While post-acute …

Cell-free DNA methylation reveals cell-specific tissue injury and correlates with disease severity and patient outcomes in COVID-19

YY Li, MM Yuan, YY Li, S Li, JD Wang, YF Wang… - Clinical …, 2024 - Springer
Background The recently identified methylation patterns specific to cell type allows the
tracing of cell death dynamics at the cellular level in health and diseases. This study used …

[HTML][HTML] Post-COVID-19 Pain Is Not Associated with DNA Methylation Levels of the ACE2 Promoter in COVID-19 Survivors Hospitalized Due to SARS-CoV-2 Infection

C Fernández-de-las-Peñas, G Díaz-Gil, A Gil-Crujera… - Biomedicines, 2024 - mdpi.com
One of theories explaining the development of long-lasting symptoms after an acute severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection include changes in the …

DNA Methylation Levels of the ACE2 Promoter Are Not Associated with Post-COVID-19 Symptoms in Individuals Who Had Been Hospitalized Due to COVID-19

C Fernández-de-Las-Peñas, G Díaz-Gil, A Gil-Crujera… - Microorganisms, 2024 - mdpi.com
It is known that SARS-CoV-2 can translocate via membrane ACE2 exopeptidase into the
host cells, and thus hypomethylation of ACE2 possibly upregulates its expression …

[图书][B] Persistent Blood DNA Methylation Changes One-Year after Covid-19

JM Balnis - 2023 - search.proquest.com
Objective: We and others have recently described outcome associated multi-omic profiles of
COVID-19 patients however, specific mechanisms regulating these differences remain …

[引用][C] DNA methylation levels of the ACE2 promoter are not associated with symptoms-severity and related-disability in previously hospitalized COVID-19 survivors

C Fernández-de-Las-Peñas, G Díaz-Gil… - European Journal of …, 2024 - ejinme.com
The presence of long-lasting symptoms after suffering an acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection has recently extensive attention in the last years. One …