A new switch for TGFβ in cancer
The TGFβ cytokine plays dichotomous roles during tumor progression. In normal and
premalignant cancer cells, the TGFβ signaling pathway inhibits proliferation and promotes …
premalignant cancer cells, the TGFβ signaling pathway inhibits proliferation and promotes …
The regulation of cell-cell adhesion during epithelial-mesenchymal transition, motility and tumor progression
GF Le Bras, KJ Taubenslag, CD Andl - Cell adhesion & migration, 2012 - Taylor & Francis
Adherens junctions (AJs) are essential for the maintenance of epithelial homeostasis and a
key factor in the regulation of cell migration and tumor progression. AJs maintain cell-cell …
key factor in the regulation of cell migration and tumor progression. AJs maintain cell-cell …
[HTML][HTML] The roles of glutathione peroxidases during embryo development
C Ufer, CC Wang - Frontiers in molecular neuroscience, 2011 - frontiersin.org
Embryo development relies on the complex interplay of the basic cellular processes
including proliferation, differentiation and apoptotic cell death. Precise regulation of these …
including proliferation, differentiation and apoptotic cell death. Precise regulation of these …
[HTML][HTML] Autocrine TGF-β in cancer: review of the literature and caveats in experimental analysis
H Ungefroren - International journal of molecular sciences, 2021 - mdpi.com
Autocrine signaling is defined as the production and secretion of an extracellular mediator
by a cell followed by the binding of that mediator to receptors on the same cell to initiate …
by a cell followed by the binding of that mediator to receptors on the same cell to initiate …
[HTML][HTML] Disabled-2 (DAB2): A Key Regulator of Anti- and Pro-Tumorigenic Pathways
Disabled-2 (DAB2), a key adaptor protein in clathrin mediated endocytosis, is implicated in
the regulation of key signalling pathways involved in homeostasis, cell positioning and …
the regulation of key signalling pathways involved in homeostasis, cell positioning and …
[HTML][HTML] DNAJB6 promotes ferroptosis in esophageal squamous cell carcinoma
B Jiang, YQ Zhao, MO Shi, L Song, Q Wang… - Digestive Diseases and …, 2020 - Springer
Abstract Background DnaJ/Hsp40 homolog, subfamily B, member 6 (DNAJB6) is
significantly down-regulated in esophageal squamous cell carcinoma (ESCC), while its …
significantly down-regulated in esophageal squamous cell carcinoma (ESCC), while its …
[HTML][HTML] Multi-omics characterization of the monkeypox virus infection
Multiple omics analyzes of Vaccinia virus (VACV) infection have defined molecular
characteristics of poxvirus biology. However, little is known about the monkeypox (mpox) …
characteristics of poxvirus biology. However, little is known about the monkeypox (mpox) …
Disabled‐2: A modular scaffold protein with multifaceted functions in signaling
CV Finkielstein, DGS Capelluto - Bioessays, 2016 - Wiley Online Library
Disabled‐2 (Dab2) is a multimodular scaffold protein with signaling roles in the domains of
cell growth, trafficking, differentiation, and homeostasis. Emerging evidences place Dab2 as …
cell growth, trafficking, differentiation, and homeostasis. Emerging evidences place Dab2 as …
[HTML][HTML] Disabled-2: a protein up-regulated by high molecular weight hyaluronan has both tumor promoting and tumor suppressor roles in ovarian cancer
Although the pro-tumorigenic functions of hyaluronan (HA) are well documented there is
limited information on the effects and targets of different molecular weight HA. Here, we …
limited information on the effects and targets of different molecular weight HA. Here, we …
[HTML][HTML] miR-134-5p promotes stage I lung adenocarcinoma metastasis and chemoresistance by targeting DAB2
L Zhang, P Huang, Q Li, D Wang, CX Xu - Molecular Therapy-Nucleic Acids, 2019 - cell.com
Despite surgery and adjuvant therapy, early-stage lung adenocarcinoma (LUAD) treatment
often fails due to local or metastatic recurrence. However, the mechanism is largely …
often fails due to local or metastatic recurrence. However, the mechanism is largely …