The TGFβ cytokine plays dichotomous roles during tumor progression. In normal and
premalignant cancer cells, the TGFβ signaling pathway inhibits proliferation and promotes …

Adherens junctions (AJs) are essential for the maintenance of epithelial homeostasis and a
key factor in the regulation of cell migration and tumor progression. AJs maintain cell-cell …

Embryo development relies on the complex interplay of the basic cellular processes
including proliferation, differentiation and apoptotic cell death. Precise regulation of these …

Autocrine signaling is defined as the production and secretion of an extracellular mediator
by a cell followed by the binding of that mediator to receptors on the same cell to initiate …

Disabled-2 (DAB2), a key adaptor protein in clathrin mediated endocytosis, is implicated in
the regulation of key signalling pathways involved in homeostasis, cell positioning and …

Abstract Background DnaJ/Hsp40 homolog, subfamily B, member 6 (DNAJB6) is
significantly down-regulated in esophageal squamous cell carcinoma (ESCC), while its …

Multiple omics analyzes of Vaccinia virus (VACV) infection have defined molecular
characteristics of poxvirus biology. However, little is known about the monkeypox (mpox) …

Disabled‐2 (Dab2) is a multimodular scaffold protein with signaling roles in the domains of
cell growth, trafficking, differentiation, and homeostasis. Emerging evidences place Dab2 as …

Although the pro-tumorigenic functions of hyaluronan (HA) are well documented there is
limited information on the effects and targets of different molecular weight HA. Here, we …

Despite surgery and adjuvant therapy, early-stage lung adenocarcinoma (LUAD) treatment
often fails due to local or metastatic recurrence. However, the mechanism is largely …