Metastatic dissemination occurs very early in the malignant progression of a cancer but the
clinical manifestation of metastases often takes years. In recent decades, 5-year survival of …

Context.—There have been major advances in the understanding of melanoma since the
last revision of the World Health Organization (WHO) classification in 2006. Objective.—To …

Over the past few years, the NCCN Guidelines for Melanoma: Cutaneous have been
expanded to include pathways for treatment of microscopic satellitosis (added in v2. 2020) …

Purpose To determine whether density and distribution of tumor-infiltrating lymphocytes
(TILs; TIL grade) is an independent predictor of sentinel lymph node (SLN) status and …

The field of systemic cancer therapy for metastatic disease has entered an exciting era with
the advent of novel immunomodulatory strategies targeting immune checkpoints. At the …

Melanoma is a lethal melanocytic neoplasm. Unfortunately, the histological diagnosis can
be difficult at times. Distinguishing ambiguous melanocytic neoplasms that are benign nevi …

Cell for cell, probably no human cancer is as aggressive as melanoma. It is among a handful
of cancers whose dimensions are reported in millimeters. Tumor thickness approaching 4 …

This book provides an authoritative guide to the histological and genetic typing of human
tumors of the skin. This volume covers keratinocytic, melanocytic, appendageal …

The incidence of cutaneous malignant melanoma has rapidly increased in recent years in all
parts of the world, and melanoma is a leading cause of cancer death. As even relatively …

Purpose Most patients with melanoma have microscopically thin (≤ 1 mm) primary lesions
and are cured with excision. However, some develop metastatic disease that is often fatal …