Rapid developments in Regenerative Medicine and Tissue Engineering has witnessed an
increasing drive toward clinical translation of breakthrough technologies. However, the …

The increasing life expectancy of humans has led to a growing numbers of patients with
chronic diseases and end-stage organ failure. Transplantation is an effective approach for …

Background Xenografts from genetically modified pigs have become one of the most
promising solutions to the dearth of human organs available for transplantation. The …

The clinical applicability of porcine xenotransplantation—a long-investigated alternative to
the scarce availability of human organs for patients with organ failure—is limited by …

Background Cross-species immunological incompatibilities have hampered pig-to-human
xenotransplantation, but porcine genome engineering recently enabled the first successful …

In humans, several grams of IgA are secreted every day in the intestinal lumen. While only
one IgA isotype exists in mice, humans secrete IgA1 and IgA2, whose respective relations …

The success of organ transplantation is limited by the complications of immunosuppression,
by chronic rejection, and by the insufficient organ supply, and thousands of patients die …

To diminish the learning curve associated with using swine as models, Swine in the
Laboratory: Surgery, Anesthesia, Imaging, and Experimental Techniques, Second Edition …

Transplantation is often the last resort for end-stage organ failures, eg, kidney, liver, heart,
lung, and pancreas. The shortage of donor organs is the main limiting factor for successful …

Xenotransplantation has the potential to alleviate the organ shortage that prevents many
patients with end‐stage renal disease from enjoying the benefits of kidney transplantation …