The multiple functions of RNA helicases as drivers and regulators of gene expression
CF Bourgeois, F Mortreux, D Auboeuf - Nature reviews Molecular cell …, 2016 - nature.com
RNA helicases comprise the largest family of enzymes involved in the metabolism of
mRNAs, the processing and fate of which rely on their packaging into messenger …
mRNAs, the processing and fate of which rely on their packaging into messenger …
[HTML][HTML] Melatonin: regulation of biomolecular condensates in neurodegenerative disorders
Biomolecular condensates are membraneless organelles (MLOs) that form dynamic,
chemically distinct subcellular compartments organizing macromolecules such as proteins …
chemically distinct subcellular compartments organizing macromolecules such as proteins …
RNA helicase DDX6 and scaffold protein GW182 in P-bodies promote biogenesis of stress granules
V Majerciak, T Zhou, MJ Kruhlak… - Nucleic Acids …, 2023 - academic.oup.com
Two prominent cytoplasmic RNA granules, ubiquitous RNA-processing bodies (PB) and
inducible stress granules (SG), regulate mRNA translation and are intimately related. In this …
inducible stress granules (SG), regulate mRNA translation and are intimately related. In this …
[HTML][HTML] Translation repressors, an RNA helicase, and developmental cues control RNP phase transitions during early development
A Hubstenberger, SL Noble, C Cameron, TC Evans - Developmental cell, 2013 - cell.com
Like membranous organelles, large-scale coassembly of macromolecules can organize
functions in cells. Ribonucleoproteins (RNPs) can form liquid or solid aggregates, but control …
functions in cells. Ribonucleoproteins (RNPs) can form liquid or solid aggregates, but control …
[HTML][HTML] Who regulates whom? An overview of RNA granules and viral infections
N Poblete-Durán, Y Prades-Pérez, J Vera-Otarola… - Viruses, 2016 - mdpi.com
After viral infection, host cells respond by mounting an anti-viral stress response in order to
create a hostile atmosphere for viral replication, leading to the shut-off of mRNA translation …
create a hostile atmosphere for viral replication, leading to the shut-off of mRNA translation …
[HTML][HTML] RNA helicase DDX3: a double-edged sword for viral replication and immune signaling
DDX3 is a cellular ATP-dependent RNA helicase involved in different aspects of RNA
metabolism ranging from transcription to translation and therefore, DDX3 participates in the …
metabolism ranging from transcription to translation and therefore, DDX3 participates in the …
Targeting DEAD‐box RNA helicases: The emergence of molecular staples
RNA helicases constitute a large family of proteins that play critical roles in mediating RNA
function. They have been implicated in all facets of gene expression pathways involving …
function. They have been implicated in all facets of gene expression pathways involving …
[HTML][HTML] Melatonin: Regulation of viral phase separation and Epitranscriptomics in post-acute sequelae of COVID-19
The relentless, protracted evolution of the SARS-CoV-2 virus imposes tremendous pressure
on herd immunity and demands versatile adaptations by the human host genome to counter …
on herd immunity and demands versatile adaptations by the human host genome to counter …
Biological functions, regulatory mechanisms, and disease relevance of RNA localization pathways
S Bovaird, D Patel, JCA Padilla, E Lécuyer - FEBS letters, 2018 - Wiley Online Library
The asymmetric subcellular distribution of RNA molecules from their sites of transcription to
specific compartments of the cell is an important aspect of post‐transcriptional gene …
specific compartments of the cell is an important aspect of post‐transcriptional gene …
[HTML][HTML] LC-MS/MS analysis of lesional and normally looking psoriatic skin reveals significant changes in protein metabolism and RNA processing
VV Sobolev, AV Mezentsev, RH Ziganshin… - PLoS …, 2021 - journals.plos.org
Background Plaque psoriasis is a chronic autoimmune disorder characterized by the
development of red scaly plaques. To date psoriasis lesional skin transcriptome has been …
development of red scaly plaques. To date psoriasis lesional skin transcriptome has been …