Cell death resistance is a key feature of tumor cells. One of the main anticancer therapies is
increasing the susceptibility of cells to death. Cancer cells have developed a capability of …

Immunogenic profile of certain cancer cell death mechanisms has been transmuted by
research published over a period of last few years and this change has been so drastic that …

To study the efficiency of RNA‐based vaccines, RNA coding for the model antigen β‐
galactosidase (β‐gal) was transcribed in vitro from a lacZ gene flanked by stabilizing …

Stress or heat shock proteins (HSPs) are the most conserved proteins present in both
prokaryotes and eukaryotes. Their expression is induced in response to a wide variety of …

Apoptotic cell death is initiated by a morphologically homogenous entity that was considered
to be non-immunogenic and non-inflammatory in nature. However, recent advances suggest …

The heat shock protein Gp96 has been shown to induce specific immune responses. On one
hand, this phenomenon is based on the specific interaction with CD91 that mediates …

Tumor drug resistance significantly limits the success of chemotherapy in the clinic. Tumor
cells utilize multiple mechanisms to prevent the accumulation of anticancer drugs at their …

Purpose: The 14 amino acid sequence (aa450–463) TKDNNLLGRFELSG (TKD) of heat
shock protein 70 (Hsp70) was identified as a tumor-selective recognition structure for natural …

Our study demonstrates that tumor-derived heat shock protein (HSP) 70 chaperones a
tyrosinase peptide and mediates its transfer to human immature dendritic cells (DCs) by …

Heat shock proteins (HSPs) like glycoprotein (gp) 96 (glucose-regulated protein 94 [grp94])
are able to induce specific cytotoxic T lymphocyte (CTL) responses against cells from which …