Portrait of the PI3K/AKT pathway in colorectal cancer
SA Danielsen, PW Eide, A Nesbakken, T Guren… - … et Biophysica Acta (BBA …, 2015 - Elsevier
Abstract PI3K/AKT signaling leads to reduced apoptosis, stimulates cell growth and
increases proliferation. Under normal conditions, PI3K/AKT activation is tightly controlled …
increases proliferation. Under normal conditions, PI3K/AKT activation is tightly controlled …
Role of the insulin-like growth factor family in cancer development and progression
H Yu, T Rohan - Journal of the National Cancer Institute, 2000 - academic.oup.com
The insulin-like growth factors (IGFs) are mitogens that play a pivotal role in regulating cell
proliferation, differentiation, and apoptosis. The effects of IGFs are mediated through the IGF …
proliferation, differentiation, and apoptosis. The effects of IGFs are mediated through the IGF …
The role of the IGF system in cancer growth and metastasis: overview and recent insights
IGF-I receptor (IGF-IR) signaling and functions are mediated through the activities of a
complex molecular network of positive (eg., type I IGF) and negative (eg., the type II IGF …
complex molecular network of positive (eg., type I IGF) and negative (eg., the type II IGF …
IGF2 and cancer
C Livingstone - Endocrine-related cancer, 2013 - erc.bioscientifica.com
Insulin-like growth factor 2 (IGF2) is a 7.5 kDa mitogenic peptide hormone expressed by liver
and many other tissues. It is three times more abundant in serum than IGF1, but our …
and many other tissues. It is three times more abundant in serum than IGF1, but our …
Insulin receptor and cancer
A Belfiore, R Malaguarnera - Endocrine-related cancer, 2011 - erc.bioscientifica.com
Carrying excess body fat is a leading cause of cancer. Epidemiologic evidence gives strong
clues about the mechanisms that link excess adiposity to risk for several cancer sites. For …
clues about the mechanisms that link excess adiposity to risk for several cancer sites. For …
The role of the IGF system in cancer: from basic to clinical studies and clinical applications
SJ Moschos, CS Mantzoros - Oncology, 2002 - karger.com
Insulin-like growth factors (IGFs) are important mediators of growth, development, and
survival, are synthesized by almost any tissue in the body, and their action is modulated by a …
survival, are synthesized by almost any tissue in the body, and their action is modulated by a …
Wnt/beta-catenin/tcf signaling: a critical pathway in gastrointestinal tumorigenesis
Cancers of the gastrointestinal tract, including the liver, bile ducts, and pancreas, constitute
the largest group of malignant tumors. Colorectal cancer is one of the most common …
the largest group of malignant tumors. Colorectal cancer is one of the most common …
Modifying IGF1 activity: an approach to treat endocrine disorders, atherosclerosis and cancer
DR Clemmons - Nature reviews Drug discovery, 2007 - nature.com
Insulin-like growth factor 1 (IGF1) is a polypeptide hormone that has a high degree of
structural similarity to human proinsulin. Owing to its ubiquitous nature and its role in …
structural similarity to human proinsulin. Owing to its ubiquitous nature and its role in …
Expression of the type 1 insulin-like growth factor receptor is up-regulated in primary prostate cancer and commonly persists in metastatic disease
GO Hellawell, GDH Turner, DR Davies, R Poulsom… - Cancer research, 2002 - AACR
The type 1 insulin-like growth factor receptor (IGF1R) mediates tumor cellgrowth, adhesion,
and protection from apoptosis. High plasma IGF-I levels predispose to prostate cancer, but …
and protection from apoptosis. High plasma IGF-I levels predispose to prostate cancer, but …
β-catenin—a linchpin in colorectal carcinogenesis?
NACS Wong, M Pignatelli - The American journal of pathology, 2002 - Elsevier
An important role for β-catenin pathways in colorectal carcinogenesis was first suggested by
the protein's association with adenomatous polyposis coli (APC) protein, and by evidence of …
the protein's association with adenomatous polyposis coli (APC) protein, and by evidence of …