Bacterial pathogens exploit a huge range of niches within their hosts. Many pathogens can
invade non-phagocytic cells and survive within a membrane-bound compartment. However …

The innate immune system plays a crucial role in the rapid recognition and elimination of
invading microbes. Detection of microbes relies on germ‐line encoded pattern recognition …

Francisella tularensis, the causative agent of tularemia, infects host macrophages, which
triggers production of the proinflammatory cytokines interleukin 1β (IL-1β) and IL-18. We …

Inflammasomes are critical for mounting host defense against pathogens. The molecular
mechanisms that control activation of the AIM2 inflammasome in response to different …

Francisella tularensis is a highly infectious gram-negative coccobacillus that causes the
zoonosis tularemia. This bacterial pathogen causes a plague-like disease in humans after …

Francisella tularensis is a pathogenic bacterium whose virulence is linked to its ability to
replicate within the host cell cytosol. Entry into the macrophage cytosol activates a host …

Francisella tularensis subverts the immune system to rapidly grow within mammalian hosts,
often causing tularemia, a fatal disease. This pathogen targets the cytosol of macrophages …

Francisella tularensis is a zoonotic intracellular pathogen and the causative agent of the
debilitating febrile illness tularemia. Although natural infections by F. tularensis are sporadic …

Francisella tularensis, the causative agent of tularemia, is one of the most infectious
bacterial pathogens known and is a category A select agent. We created a sequence …

Tularemia is a zoonosis of humans caused by infection with the facultative intracellular
bacterium Francisella tularensis. Interest in F. tularensis has increased markedly in the past …