In the mammalian central nervous system, excitatory glutamatergic synapses harness
neurotransmission that is mediated by ion flow through α-amino-3-hydroxy-5-methyl-4 …

Cellular responses to environmental cues involve the mobilization of GTPases, protein
kinases and phosphoprotein phosphatases. The spatial organization of these signalling …

Proteins perform most cellular functions in macromolecular complexes. The same protein
often participates in different complexes to exhibit diverse functionality. Current ensemble …

Even in healthy individuals there is an inexorable agerelated decline in cognitive function.
This is due, in large part, to reduced synaptic plasticity caused by changes in the molecular …

Information processing in the brain requires multiple forms of synaptic plasticity that
converge on regulation of NMDA and AMPA-type glutamate receptors (NMDAR, AMPAR) …

Regulatory enzymes often have different roles in distinct subcellular compartments. Yet,
most drugs indiscriminately saturate the cell. Thus, subcellular drug-delivery holds promise …

Neuronal Kv7 channels underlie a voltage-gated non-inactivating potassium current known
as the M-current. Due to its particular characteristics, Kv7 channels show pronounced …

Endothelial cell dysfunction, characterized by a diminished response to endothelial cell–
dependent vasodilators, is a hallmark of hypertension. TRPV4 channels play a major role in …

The formation of multiprotein complexes is a repeated theme in biology ranging from the
regulation of the extracellular signal-regulated kinase and cAMP signaling pathways to the …

Experience-dependent learning and memory require multiple forms of plasticity at
hippocampal and cortical synapses that are regulated by N-methyl-D-aspartate receptors …