Base editing: advances and therapeutic opportunities
EM Porto, AC Komor, IM Slaymaker… - Nature Reviews Drug …, 2020 - nature.com
Base editing—the introduction of single-nucleotide variants (SNVs) into DNA or RNA in
living cells—is one of the most recent advances in the field of genome editing. As around …
living cells—is one of the most recent advances in the field of genome editing. As around …
MicroRNA involvement in signaling pathways during viral infection
MG Barbu, CE Condrat, DC Thompson… - Frontiers in cell and …, 2020 - frontiersin.org
The study of miRNAs started in 1993, when Lee et al. observed their involvement in the
downregulation of a crucial protein known as LIN-14 in the nematode Caenorhabditis …
downregulation of a crucial protein known as LIN-14 in the nematode Caenorhabditis …
[图书][B] Organism and environment: ecological development, niche construction, and adaptation
SE Sultan - 2015 - books.google.com
Over the past decade, advances in both molecular developmental biology and evolutionary
ecology have made possible a new understanding of organisms as dynamic systems …
ecology have made possible a new understanding of organisms as dynamic systems …
In vivo base editing of post-mitotic sensory cells
Programmable nucleases can introduce precise changes to genomic DNA through
homology-directed repair (HDR). Unfortunately, HDR is largely restricted to mitotic cells, and …
homology-directed repair (HDR). Unfortunately, HDR is largely restricted to mitotic cells, and …
Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways
More than 2% of adults harbor a pancreatic cyst, a subset of which progresses to invasive
lesions with lethal consequences. To assess the genomic landscapes of neoplastic cysts of …
lesions with lethal consequences. To assess the genomic landscapes of neoplastic cysts of …
Cancer-associated fibroblasts induce epithelial–mesenchymal transition of bladder cancer cells through paracrine IL-6 signalling
Abstract Background Cancer-associated fibroblasts (CAFs), activated by tumour cells, are
the predominant type of stromal cells in cancer tissue and play an important role in …
the predominant type of stromal cells in cancer tissue and play an important role in …
Wnt/β-catenin signalling in prostate cancer
RM Kypta, J Waxman - Nature Reviews Urology, 2012 - nature.com
The Wnts are secreted cysteine-rich glycoproteins that have important roles in the
developing embryo as well as in tissue homeostasis in adults. Dysregulation of Wnt …
developing embryo as well as in tissue homeostasis in adults. Dysregulation of Wnt …
[HTML][HTML] Modulation of the Wnt pathway through inhibition of CLK2 and DYRK1A by lorecivivint as a novel, potentially disease-modifying approach for knee …
V Deshmukh, AL O'Green, C Bossard, T Seo… - Osteoarthritis and …, 2019 - Elsevier
Objectives Wnt pathway upregulation contributes to knee osteoarthritis (OA) through
osteoblast differentiation, increased catabolic enzymes, and inflammation. The small …
osteoblast differentiation, increased catabolic enzymes, and inflammation. The small …
Wnt/beta-catenin signaling and small molecule inhibitors
A Voronkov, S Krauss - Current pharmaceutical design, 2013 - ingentaconnect.com
Wnt/β-catenin signaling is a branch of a functional network that dates back to the first
metazoans and it is involved in a broad range of biological systems including stem cells …
metazoans and it is involved in a broad range of biological systems including stem cells …
The WNT signaling pathway from ligand secretion to gene transcription: molecular mechanisms and pharmacological targets
HA Baarsma, M Königshoff, R Gosens - Pharmacology & therapeutics, 2013 - Elsevier
Wingless/integrase-1 (WNT) signaling is a key pathway regulating various aspects of
embryonic development; however it also underlies several pathological conditions in man …
embryonic development; however it also underlies several pathological conditions in man …