Development of multifunctional molecules as potential therapeutic candidates for Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis in the …

MG Savelieff, G Nam, J Kang, HJ Lee, M Lee… - Chemical …, 2018 - ACS Publications
Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …

The mucosal immune system of teleost fish

I Salinas - Biology, 2015 - mdpi.com
Teleost fish possess an adaptive immune system associated with each of their mucosal
body surfaces. Evidence obtained from mucosal vaccination and mucosal infection studies …

Insulin resistance and Alzheimer's disease: bioenergetic linkages

BJ Neth, S Craft - Frontiers in aging neuroscience, 2017 - frontiersin.org
Metabolic dysfunction is a well-established feature of Alzheimer's disease (AD), evidenced
by brain glucose hypometabolism that can be observed potentially decades prior to the …

Docosahexaenoic acid signalolipidomics in nutrition: significance in aging, neuroinflammation, macular degeneration, Alzheimer's, and other neurodegenerative …

NG Bazan, MF Molina, WC Gordon - Annual review of nutrition, 2011 - annualreviews.org
Essential polyunsaturated fatty acids (PUFAs) are critical nutritional lipids that must be
obtained from the diet to sustain homeostasis. Omega-3 and-6 PUFAs are key components …

[HTML][HTML] Increased excitotoxicity and neuroinflammatory markers in postmortem frontal cortex from bipolar disorder patients

JS Rao, GJ Harry, SI Rapoport, HW Kim - Molecular psychiatry, 2010 - nature.com
Reports of cognitive decline, symptom worsening and brain atrophy in bipolar disorder (BD)
suggest that the disease progresses over time. The worsening neuropathology may involve …

Oxidative stress in anxiety and comorbid disorders

I Hovatta, J Juhila, J Donner - Neuroscience research, 2010 - Elsevier
Anxiety disorders, depression, and alcohol use disorder are common neuropsychiatric
diseases that often occur together. Oxidative stress has been suggested to contribute to their …

Modulation of inflammation in brain: a matter of fat

AA Farooqui, LA Horrocks… - Journal of …, 2007 - Wiley Online Library
Neuroinflammation is a host defense mechanism associated with neutralization of an insult
and restoration of normal structure and function of brain. Neuroinflammation is a hallmark of …

Neuroprotectin D1 (NPD1): a DHA‐derived mediator that protects brain and retina against cell injury‐induced oxidative stress

NG Bazan - Brain pathology, 2005 - Wiley Online Library
The biosynthesis of oxygenated arachidonic acid messengers triggered by cerebral
ischemia‐reperfusion is preceded by an early and rapid phospholipase A2 activation …

Phospholipase A2, reactive oxygen species, and lipid peroxidation in cerebral ischemia

RM Adibhatla, JF Hatcher - Free Radical Biology and Medicine, 2006 - Elsevier
Ischemic stroke is caused by obstruction of blood flow to the brain, resulting in energy failure
that initiates a complex series of metabolic events, ultimately causing neuronal death. One …

Multi-target-directed ligands and other therapeutic strategies in the search of a real solution for Alzheimer's disease

A Agis-Torres, M Sollhuber… - Current …, 2014 - ingentaconnect.com
The lack of an adequate therapy for Alzheimer's Disease (AD) contributes greatly to the
continuous growing amount of papers and reviews, reflecting the important efforts made by …