Development of multifunctional molecules as potential therapeutic candidates for Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis in the …
Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …
The mucosal immune system of teleost fish
I Salinas - Biology, 2015 - mdpi.com
Teleost fish possess an adaptive immune system associated with each of their mucosal
body surfaces. Evidence obtained from mucosal vaccination and mucosal infection studies …
body surfaces. Evidence obtained from mucosal vaccination and mucosal infection studies …
Insulin resistance and Alzheimer's disease: bioenergetic linkages
BJ Neth, S Craft - Frontiers in aging neuroscience, 2017 - frontiersin.org
Metabolic dysfunction is a well-established feature of Alzheimer's disease (AD), evidenced
by brain glucose hypometabolism that can be observed potentially decades prior to the …
by brain glucose hypometabolism that can be observed potentially decades prior to the …
Docosahexaenoic acid signalolipidomics in nutrition: significance in aging, neuroinflammation, macular degeneration, Alzheimer's, and other neurodegenerative …
NG Bazan, MF Molina, WC Gordon - Annual review of nutrition, 2011 - annualreviews.org
Essential polyunsaturated fatty acids (PUFAs) are critical nutritional lipids that must be
obtained from the diet to sustain homeostasis. Omega-3 and-6 PUFAs are key components …
obtained from the diet to sustain homeostasis. Omega-3 and-6 PUFAs are key components …
[HTML][HTML] Increased excitotoxicity and neuroinflammatory markers in postmortem frontal cortex from bipolar disorder patients
Reports of cognitive decline, symptom worsening and brain atrophy in bipolar disorder (BD)
suggest that the disease progresses over time. The worsening neuropathology may involve …
suggest that the disease progresses over time. The worsening neuropathology may involve …
Oxidative stress in anxiety and comorbid disorders
I Hovatta, J Juhila, J Donner - Neuroscience research, 2010 - Elsevier
Anxiety disorders, depression, and alcohol use disorder are common neuropsychiatric
diseases that often occur together. Oxidative stress has been suggested to contribute to their …
diseases that often occur together. Oxidative stress has been suggested to contribute to their …
Modulation of inflammation in brain: a matter of fat
AA Farooqui, LA Horrocks… - Journal of …, 2007 - Wiley Online Library
Neuroinflammation is a host defense mechanism associated with neutralization of an insult
and restoration of normal structure and function of brain. Neuroinflammation is a hallmark of …
and restoration of normal structure and function of brain. Neuroinflammation is a hallmark of …
Neuroprotectin D1 (NPD1): a DHA‐derived mediator that protects brain and retina against cell injury‐induced oxidative stress
NG Bazan - Brain pathology, 2005 - Wiley Online Library
The biosynthesis of oxygenated arachidonic acid messengers triggered by cerebral
ischemia‐reperfusion is preceded by an early and rapid phospholipase A2 activation …
ischemia‐reperfusion is preceded by an early and rapid phospholipase A2 activation …
Phospholipase A2, reactive oxygen species, and lipid peroxidation in cerebral ischemia
RM Adibhatla, JF Hatcher - Free Radical Biology and Medicine, 2006 - Elsevier
Ischemic stroke is caused by obstruction of blood flow to the brain, resulting in energy failure
that initiates a complex series of metabolic events, ultimately causing neuronal death. One …
that initiates a complex series of metabolic events, ultimately causing neuronal death. One …
Multi-target-directed ligands and other therapeutic strategies in the search of a real solution for Alzheimer's disease
A Agis-Torres, M Sollhuber… - Current …, 2014 - ingentaconnect.com
The lack of an adequate therapy for Alzheimer's Disease (AD) contributes greatly to the
continuous growing amount of papers and reviews, reflecting the important efforts made by …
continuous growing amount of papers and reviews, reflecting the important efforts made by …