▪ Abstract The synthesis and excretion of bile acids comprise the major pathway of
cholesterol catabolism in mammals. Synthesis provides a direct means of converting …

The use of animal models, particularly genetically modified mice, continues to play a critical
role in studying the relationship between bile acid metabolism and human liver disease …

Cholesterol degradation to bile acids in the liver can be initiated by either cholesterol 7a-
hydroxylase (CYP7A1) of the classic (neutral) pathway, or by mitochondrial sterol 27 …

Neuroactive steroids synthesized in neuronal tissue, referred to as neurosteroids, are
implicated in proliferation, differentiation, activity and survival of nerve cells. Neurosteroids …

The classic view of brain sexual differentiation and behavior is that gonadal steroid
hormones act directly to promote sex differences in neural and behavioral development. In …

Much of P450 research has always been done with the view of appUcation to humans, even
when done with experimental animals and microorganisms. Research with the human …

Summary 7α, 25-dihydroxycholesterol (7α, 25-OHC) is a ligand for the G protein-coupled
receptor EBI2; however, the cellular sources of this oxysterol are undefined. 7α, 25-OHC is …

The present review describes the transgenic mouse models that have been designed to
evaluate the functions of the cytochrome P450s involved in cholesterol and bile acid …

Epithelial proliferation of the ventral prostate in rodents peaks between 2 and 4 weeks of
age, and by week 8, proliferating cells are rare. We have used ERβ−/− and CYP7B1−/− mice …

Background Aging is accompanied by increasing vulnerability to pathologies such as
atherosclerosis (ATH) and Alzheimer disease (AD). Are these different pathologies, or …