ABSTRACT A comprehensive understanding of the neurobiology of alcohol cue reactivity is
critical in identifying the neuropathology of alcohol use disorders (AUD) and developing …

Background: Imaging techniques have been in widespread use in the scientific community
for more than 3 decades. They facilitate noninvasive, in vivo studies of the human brain in …

Aims During the development of drug addiction, initial hedonic effects decrease when
substance use becomes habitual and ultimately compulsive. Animal research suggests that …

Context In alcohol-dependent patients, brain atrophy and functional brain activation elicited
by alcohol-associated stimuli may predict relapse. However, to date, the interaction between …

Altered brain responses to alcohol-associated stimuli are a neural hallmark of alcohol-use
disorder (AUD) and a promising target for pharmacotherapy. However, findings in cue …

Addictions are commonly presaged by problems in childhood and adolescence. For many
individuals this starts with the early expression of impulsive risk-taking, social …

A growing number of imaging studies suggest that alcohol cues, mainly visual, elicit
activation in mesocorticolimbic structures. Such findings are consistent with the growing …

Although numerous studies provide general support for the importance of genetic factors in
the risk for alcohol use disorders (AUDs), candidate gene and genome-wide studies have …

BACKGROUND:: Substance-abusing individuals tend to display abnormal reward
processing and a vulnerability to being impulsive. Detoxified alcoholics show differences in …

The incentive salience sensitization (ISS) theory of addiction holds that addictive behavior
stems from the ability of drugs to progressively sensitize the brain circuitry that mediates …