Targeting the gut and tumor microbiota in cancer

EM Park, M Chelvanambi, N Bhutiani, G Kroemer… - Nature medicine, 2022 - nature.com
Microorganisms within the gut and other niches may contribute to carcinogenesis, as well as
shaping cancer immunosurveillance and response to immunotherapy. Our understanding of …

The role of short-chain fatty acids in immunity, inflammation and metabolism

Y Yao, X Cai, W Fei, Y Ye, M Zhao… - Critical reviews in food …, 2022 - Taylor & Francis
Short-chain fatty acids (SCFAs) are carboxylic acids with carbon atom numbers less than 6,
which are important metabolites of gut microbiome. Existing research shows that SCFAs …

[HTML][HTML] Role of microbiota-derived short-chain fatty acids in cancer development and prevention

R Mirzaei, A Afaghi, S Babakhani, MR Sohrabi… - Biomedicine & …, 2021 - Elsevier
Following cancer, cells in a particular tissue can no longer respond to the factors involved in
controlling cell survival, differentiation, proliferation, and death. In recent years, it has been …

SCFA: mechanisms and functional importance in the gut

C Martin-Gallausiaux, L Marinelli… - Proceedings of the …, 2021 - cambridge.org
In recent years, the importance of the gut microbiota in human health has been revealed and
many publications have highlighted its role as a key component of human physiology …

[HTML][HTML] Mucus sialylation determines intestinal host-commensal homeostasis

Y Yao, G Kim, S Shafer, Z Chen, S Kubo, Y Ji, J Luo… - Cell, 2022 - cell.com
Intestinal mucus forms the first line of defense against bacterial invasion while providing
nutrition to support microbial symbiosis. How the host controls mucus barrier integrity and …

[HTML][HTML] Dual role of microbiota-derived short-chain fatty acids on host and pathogen

R Mirzaei, E Dehkhodaie, B Bouzari, M Rahimi… - Biomedicine & …, 2022 - Elsevier
A growing body of documents shows microbiota produce metabolites such as short-chain
fatty acids (SCFAs) as crucial executors of diet-based microbial influence the host and …

Tumor-resident Lactobacillus iners confer chemoradiation resistance through lactate-induced metabolic rewiring

LE Colbert, MB El Alam, R Wang, T Karpinets, D Lo… - Cancer Cell, 2023 - cell.com
Tumor microbiota can produce active metabolites that affect cancer and immune cell
signaling, metabolism, and proliferation. Here, we explore tumor and gut microbiome …

Signaling pathways in cancer metabolism: mechanisms and therapeutic targets

M You, Z Xie, N Zhang, Y Zhang, D Xiao, S Liu… - … and Targeted Therapy, 2023 - nature.com
A wide spectrum of metabolites (mainly, the three major nutrients and their derivatives) can
be sensed by specific sensors, then trigger a series of signal transduction pathways and …

Implication of gut microbiota in cardiovascular diseases

W Zhou, Y Cheng, P Zhu, MI Nasser… - Oxidative medicine …, 2020 - Wiley Online Library
Emerging evidence has identified the association between gut microbiota and various
diseases, including cardiovascular diseases (CVDs). Altered intestinal flora composition has …

The Beneficial Role of Probiotic Lactobacillus in Respiratory Diseases

T Du, A Lei, N Zhang, C Zhu - Frontiers in immunology, 2022 - frontiersin.org
Respiratory diseases cause a high incidence and mortality worldwide. As a natural
immunobiotic, Lactobacillus has excellent immunomodulatory ability. Administration of some …