Tumor hypoxia regulates immune escape/invasion: influence on angiogenesis and potential impact of hypoxic biomarkers on cancer therapies
R Abou Khouzam, K Brodaczewska, A Filipiak… - Frontiers in …, 2021 - frontiersin.org
The environmental and metabolic pressures in the tumor microenvironment (TME) play a
key role in molding tumor development by impacting the stromal and immune cell fractions …
key role in molding tumor development by impacting the stromal and immune cell fractions …
Tumor hypoxia: impact on radiation therapy and molecular pathways
BS Sørensen, MR Horsman - Frontiers in oncology, 2020 - frontiersin.org
Tumor hypoxia is a common feature of the microenvironment in solid tumors, primarily due to
an inadequate, and heterogeneous vascular network. It is associated with resistance to …
an inadequate, and heterogeneous vascular network. It is associated with resistance to …
[HTML][HTML] Identification and validation of hypoxia-derived gene signatures to predict clinical outcomes and therapeutic responses in stage I lung adenocarcinoma …
Rationale: The current tumour-node-metastasis (TNM) staging system is insufficient for
precise treatment decision-making and accurate survival prediction for patients with stage I …
precise treatment decision-making and accurate survival prediction for patients with stage I …
Divergent mutational processes distinguish hypoxic and normoxic tumours
Many primary tumours have low levels of molecular oxygen (hypoxia), and hypoxic tumours
respond poorly to therapy. Pan-cancer molecular hallmarks of tumour hypoxia remain poorly …
respond poorly to therapy. Pan-cancer molecular hallmarks of tumour hypoxia remain poorly …
Hypoxia-related lncRNA correlates with prognosis and immune microenvironment in lower-grade glioma
Background Hypoxia-related genes are demonstrated to correlate with the prognosis of
various cancers. However, the role of hypoxia-related long non-coding RNAs (HRLs) in …
various cancers. However, the role of hypoxia-related long non-coding RNAs (HRLs) in …
Hypoxia as a potential inducer of immune tolerance, tumor plasticity and a driver of tumor mutational burden: Impact on cancer immunotherapy
In cancer patients, immune cells are often functionally compromised due to the
immunosuppressive features of the tumor microenvironment (TME) which contribute to the …
immunosuppressive features of the tumor microenvironment (TME) which contribute to the …
Impact of lineage plasticity to and from a neuroendocrine phenotype on progression and response in prostate and lung cancers
Intratumoral heterogeneity can occur via phenotype transitions, often after chronic exposure
to targeted anticancer agents. This process, termed lineage plasticity, is associated with …
to targeted anticancer agents. This process, termed lineage plasticity, is associated with …
RNA sequencing for research and diagnostics in clinical oncology
Molecular diagnostics is becoming one of the major drivers of personalized oncology. With
hundreds of different approved anticancer drugs and regimens of their administration …
hundreds of different approved anticancer drugs and regimens of their administration …
Breast cancer hypoxia in relation to prognosis and benefit from radiotherapy after breast-conserving surgery in a large, randomised trial with long-term follow-up
J Tutzauer, M Sjöström, E Holmberg, P Karlsson… - British journal of …, 2022 - nature.com
Background Breast-conserving surgery followed by radiotherapy is part of standard
treatment for early-stage breast cancer. Hypoxia is common in cancer and may affect the …
treatment for early-stage breast cancer. Hypoxia is common in cancer and may affect the …
Integrating tumor hypoxic stress in novel and more adaptable strategies for cancer immunotherapy
Immunotherapy is poised to become an increasingly utilized therapy in the treatment of
cancer. However, several abnormalities in the tumor microenvironment (TME) that can …
cancer. However, several abnormalities in the tumor microenvironment (TME) that can …