A review on quantitative multiplexed proteomics
N Pappireddi, L Martin, M Wühr - Chembiochem, 2019 - Wiley Online Library
Over the last few decades, mass spectrometry‐based proteomics has become an
increasingly powerful tool that is now able to routinely detect and quantify thousands of …
increasingly powerful tool that is now able to routinely detect and quantify thousands of …
From mechanical resilience to active material properties in biopolymer networks
The cells and tissues that make up our body manage contradictory mechanical demands. It
is crucial for their survival to be able to withstand large mechanical loads, but it is equally …
is crucial for their survival to be able to withstand large mechanical loads, but it is equally …
Oocytes maintain ROS-free mitochondrial metabolism by suppressing complex I
Oocytes form before birth and remain viable for several decades before fertilization.
Although poor oocyte quality accounts for most female fertility problems, little is known about …
Although poor oocyte quality accounts for most female fertility problems, little is known about …
In silico protein interaction screening uncovers DONSON's role in replication initiation
CDC45-MCM2-7-GINS (CMG) helicase assembly is the central event in eukaryotic
replication initiation. In yeast, a multi-subunit “pre-loading complex”(pre-LC) accompanies …
replication initiation. In yeast, a multi-subunit “pre-loading complex”(pre-LC) accompanies …
Gut bacterial nutrient preferences quantified in vivo
Great progress has been made in understanding gut microbiomes' products and their effects
on health and disease. Less attention, however, has been given to the inputs that gut …
on health and disease. Less attention, however, has been given to the inputs that gut …
PEX5 translocation into and out of peroxisomes drives matrix protein import
ML Skowyra, TA Rapoport - Molecular cell, 2022 - cell.com
Peroxisomes are ubiquitous organelles whose dysfunction causes fatal human diseases.
Most peroxisomal enzymes are imported from the cytosol by the receptor PEX5, which …
Most peroxisomal enzymes are imported from the cytosol by the receptor PEX5, which …
Amyloid-like self-assembly of a cellular compartment
Most vertebrate oocytes contain a Balbiani body, a large, non-membrane-bound
compartment packed with RNA, mitochondria, and other organelles. Little is known about …
compartment packed with RNA, mitochondria, and other organelles. Little is known about …
Defining the consequences of genetic variation on a proteome-wide scale
Genetic variation modulates protein expression through both transcriptional and post-
transcriptional mechanisms. To characterize the consequences of natural genetic diversity …
transcriptional mechanisms. To characterize the consequences of natural genetic diversity …
Phase separation of TPX2 enhances and spatially coordinates microtubule nucleation
Phase separation of substrates and effectors is proposed to enhance biological reaction
rates and efficiency. Targeting protein for Xklp2 (TPX2) is an effector of branching …
rates and efficiency. Targeting protein for Xklp2 (TPX2) is an effector of branching …
The molecular basis of coupling between poly (A)-tail length and translational efficiency
In animal oocytes and early embryos, mRNA poly (A)-tail length strongly influences
translational efficiency (TE), but later in development this coupling between tail length and …
translational efficiency (TE), but later in development this coupling between tail length and …