Simple Summary Accumulating evidence indicates that hypoxia-inducible factor-1 (HIF-1)
plays a pivotal role in tumor biology, particularly in hypoxic environments. Over the past few …

ATP-binding cassette (ABC) transporters such as ABCB1, ABCG2, and ABCC1 are the
major players in drug efflux-mediated multidrug resistance (MDR), which severely affects the …

We have previously described novel histone acetyltransferase (HAT) inhibitors that block
neuroblastoma cell growth in vitro. Here we show that two selected pyridoisothiazolone HAT …

Defective clearance mechanisms lead to the accumulation of amyloid-beta (Aβ) peptides in
the Alzheimer's brain. Though predominantly generated in neurons, little is known about …

Identification of the novel (E)-N′-((2-chloro-7-methoxyquinolin-3-yl) methylene)-3-
(phenylthio) propanehydrazide scaffold 18 has led to the development of a new series of …

Multidrug resistance protein 1 (MDR1, ABCB1, P-glycoprotein) and breast cancer resistance
protein (BCRP, ABCG2) are key efflux transporters that mediate the extrusion of drugs and …

Two new series of aminoquinoline based derivatives (thiazolyl pyrazolines and pyrazolyl
thiazolidinones) were designed and synthesized. The in vitro antiporliferative activity of the …

Suberoylanilide hydroxamic acid (SAHA), a potent pan-histone deacetylase (HDAC)
inhibitor, has been clinically approved for the treatment of cutaneous T-cell lymphoma …

Background: Accounting for mortality nearly one in four of human and second highest
leading cause of death worldwide. Every year, about 10 million new cancers are diagnosed …

Background Metastatic initiation has many phenotypic similarities to epithelial-to-
mesenchymal transition, including loss of cell–cell adhesion, increased invasiveness, and …