Metastasis is the major cause of death in patients with colorectal carcinoma (CRC). The
most common sites of metastasis are the liver and the peritoneum. Peritoneal …

Colorectal cancer (CRC) is the second most common cancer in women and the third most
common in men globally. CRC arises from one or a combination of chromosomal instability …

Background: Phosphoinositide 3-kinase (PI3Ks) is a member of intracellular lipid kinases
and involved in the regulation of cellular proliferation, differentiation and survival …

Tumor metastasis is a multi-step process by which tumor cells disseminate from their primary
site and form secondary tumors at a distant site. And metastasis is the major cause of death …

Abstract PI3K/AKT signaling leads to reduced apoptosis, stimulates cell growth and
increases proliferation. Under normal conditions, PI3K/AKT activation is tightly controlled …

The purpose of this review is to highlight the recent mechanistic developments elucidating
the role of matrix metalloproteinases (MMPs) in tumour invasion and metastasis. The ability …

Understanding the etiology of metastasis is very important in clinical perspective, since it is
estimated that metastasis accounts for 90% of cancer patient mortality. Metastasis results …

Growth factor-induced activation of protein kinase-B (PKB), also known as AKT, induces pro-
survival signaling and inhibits activation of pro-apoptotic signaling molecules including the …

Background: Breast cancer stem cells (BCSCs) are characterized by high aldehyde
dehydrogenase (ALDH) enzyme activity and are refractory to current treatment modalities …

Simple Summary Angiogenesis belongs to the most clinical characteristics of colorectal
cancer (CRC) and is strongly linked to the activation of Wnt/β-catenin signaling. The most …