From poison to promise: The evolution of tetrodotoxin and its potential as a therapeutic

GM Bucciarelli, M Lechner, A Fontes, LB Kats… - Toxins, 2021 - mdpi.com
Tetrodotoxin (TTX) is a potent neurotoxin that was first identified in pufferfish but has since
been isolated from an array of taxa that host TTX-producing bacteria. However, determining …

Toxic relationships and arms-race coevolution revisited

GM Bucciarelli, F Alsalek, LB Kats… - Annual Review of …, 2022 - annualreviews.org
Toxin evolution in animals is one of the most fascinating and complex subjects of scientific
inquiry today. Gaining an understanding of toxins poses a multifaceted challenge given the …

Of poisons and parasites—the defensive role of tetrodotoxin against infections in newts

PTJ Johnson, DM Calhoun, AN Stokes… - Journal of Animal …, 2018 - Wiley Online Library
Classical research on animal toxicity has focused on the role of toxins in protection against
predators, but recent studies suggest these same compounds can offer a powerful defense …

Individual fluctuations in toxin levels affect breeding site fidelity in a chemically defended amphibian

GM Bucciarelli, DB Green… - Proceedings of the …, 2016 - royalsocietypublishing.org
Behaviours that influence habitat selection strongly determine species movement patterns.
One component of animal behaviour that largely influences movement patterns and habitat …

Feral frogs, native newts, and chemical cues: identifying threats from and management opportunities for invasive African Clawed Frogs in Washington state

D Anderson, O Cervantez, GM Bucciarelli, MR Lambert… - PeerJ, 2024 - peerj.com
Invasive species threaten biodiversity globally. Amphibians are one of the most threatened
vertebrate taxa and are particularly sensitive to invasive species, including other …

Noxious newts and their natural enemies: Experimental effects of tetrodotoxin exposure on trematode parasites and aquatic macroinvertebrates

DM Calhoun, GM Bucciarelli, LB Kats, RK Zimmer… - Toxicon, 2017 - Elsevier
The dermal glands of many amphibian species secrete toxins or other noxious substances
as a defense strategy against natural enemies. Newts in particular possess the potent …

Native amphibian toxin reduces invasive crayfish feeding with potential benefits to stream biodiversity

GM Bucciarelli, SJ Smith, JJ Choe, PD Shin… - BMC Ecology and …, 2023 - Springer
Background Biodiversity is generally reduced when non-native species invade an
ecosystem. Invasive crayfish, Procambarus clarkii, populate California freshwater streams …

An amphibian toxin phenotype is sexually dimorphic and shows seasonal concordant change between sexes

AR Frey, GM Bucciarelli, DD Hu, LB Kats… - Frontiers in Amphibian …, 2023 - frontiersin.org
Sexually dimorphic phenotypes are consequential to animal survival, and this is especially
apparent with defense phenotypes. Amphibians have poison glands, and several lineages …

[HTML][HTML] The effect of newt toxin on an invasive snail

WM Ota, B Olsen, GM Bucciarelli, LB Kats - Hydrobiologia, 2018 - Springer
Invasive species are well documented to impact native species where they are introduced.
In the Santa Monica Mountains, a native species of amphibian, the California newt (Taricha …

Are Pacific Chorus Frogs (Pseudacris regilla) Resistant to Tetrodotoxin (TTX)? Characterizing Potential TTX Exposure and Resistance in an Ecological Associate of Pacific …

KO Montana, V Ramírez-Castañeda… - Journal of …, 2023 - meridian.allenpress.com
Animals that frequently encounter toxins often develop mechanisms of toxin resistance over
evolutionary time. Both predators that consume toxic prey and organisms in physical contact …