Boosting checkpoint immunotherapy with biomaterials

L Liu, Y Pan, C Zhao, P Huang, X Chen, L Rao - ACS nano, 2023 - ACS Publications
The immune checkpoint blockade (ICB) therapy has revolutionized the field of cancer
treatment, while low response rates and systemic toxicity limit its clinical outcomes. With the …

Development of nanotechnology-mediated precision radiotherapy for anti-metastasis and radioprotection

Y Pan, W Tang, W Fan, J Zhang, X Chen - Chemical Society Reviews, 2022 - pubs.rsc.org
Radiotherapy (RT), including external beam RT and internal radiation therapy, uses high-
energy ionizing radiation to kill tumor cells. However, ionizing radiation inevitably damages …

Recent progress of metal‐based nanomaterials with anti‐tumor biological effects for enhanced cancer therapy

H Lei, Z Pei, C Jiang, L Cheng - Exploration, 2023 - Wiley Online Library
Metal‐based nanomaterials have attracted broad attention recently due to their unique
biological physical and chemical properties after entering tumor cells, namely biological …

Nanomedicine embraces cancer radio-immunotherapy: mechanism, design, recent advances, and clinical translation

H Li, Q Luo, H Zhang, X Ma, Z Gu, Q Gong… - Chemical Society …, 2023 - pubs.rsc.org
Cancer radio-immunotherapy, integrating external/internal radiation therapy with immuno-
oncology treatments, emerges in the current management of cancer. A growing number of …

A Self‐Reporting Fluorescent Salicylaldehyde–Chlorambucil Conjugate as a Type‐II ICD Inducer for Cancer Vaccines

M Zhang, X Jin, M Gao, Y Zhang… - Advanced Materials, 2022 - Wiley Online Library
Immunogenic cell death (ICD) can activate the anticancer immune response and is highly
attractive to improve cancer treatment efficacy. ICD is closely related to endoplasmic …

[HTML][HTML] Engineered tumor cell-derived vaccines against cancer: The art of combating poison with poison

X Zhang, H Cui, W Zhang, Z Li, J Gao - Bioactive Materials, 2023 - Elsevier
Tumor vaccination is a promising approach for tumor immunotherapy because it presents
high specificity and few side effects. However, tumor vaccines that contain only a single …

Biosynthetic dendritic cell-exocytosed aggregation-induced emission nanoparticles for synergistic photodynamic immunotherapy

H Cao, H Gao, L Wang, Y Cheng, X Wu, X Shen… - ACS …, 2022 - ACS Publications
Dendritic cell (DC)-derived small extracellular vesicles (DEVs) are recognized as a highly
promising alternative to DC vaccines; however, the clinical testing of DEV-based …

Metal‐cyclic dinucleotide nanomodulator‐stimulated STING signaling for strengthened radioimmunotherapy of large tumor

D Wang, T Nie, C Huang, Z Chen, X Ma, W Fang… - Small, 2022 - Wiley Online Library
Combined treatment of immunotherapy and radiotherapy shows promising therapeutic
effects for the regression of a variety of cancers. However, even multi‐modality therapies …

Four ounces can move a thousand pounds: the enormous value of nanomaterials in tumor immunotherapy

Z Chen, Z Yue, K Yang, C Shen… - Advanced …, 2023 - Wiley Online Library
The application of nanomaterials in healthcare has emerged as a promising strategy due to
their unique structural diversity, surface properties, and compositional diversity. In particular …

Melatonin as a regulator of apoptosis in leukaemia: molecular mechanism and therapeutic perspectives

A Mafi, H Rismanchi, Y Gholinezhad… - Frontiers in …, 2023 - frontiersin.org
Leukaemia is a dangerous malignancy that causes thousands of deaths every year
throughout the world. The rate of morbidity and mortality is significant despite many …