Exosomes are secreted by mammalian cells and are widely distributed in cellular systems.
They are a medium of information and material transmission. The complexity of exosome …

Virus-like particles (VLPs) are self-assembled structures derived from viral antigens that
mimic the native architecture of viruses but lack the viral genome. VLPs have emerged as a …

Lentiviral vectors (LVs) have been increasingly used as a tool for gene and cell therapies
since they can stably integrate the genome in dividing and nondividing cells. LV production …

Manufacturing of cell culture-derived virus particles for vaccination and gene therapy is a
rapidly growing field in the biopharmaceutical industry. The process involves a number of …

The interest in lentiviral vectors (LVs) has increased prominently for gene therapy
applications, but few have reached the later stages of clinical trials. The main challenge has …

Downstream processing of nanoplexes (viruses, virus-like particles, bacteriophages) is
characterized by complexity of the starting material, number of purification methods to …

Lentiviral vectors (LVs) hold great potential as gene delivery vehicles. However, the
manufacturing and purification of these vectors still present major challenges, mainly …

For centuries mankind led a difficult battle against viruses, the smallest infectious agents at
the surface of the earth. Nowadays it is possible to use viruses for our benefit, both at a …

As a result of the growing interest in the use of viruses for gene therapy and vaccines, many
virus-based products are being developed. The manufacturing of viruses poses new …

Anion-exchange chromatography is one of the separation processes of choice for the
recovery/purification of proteins and complex bio-structures as viruses or virus-like particles …