Lysosomes are catabolic organelles that contribute to the degradation of intracellular
constituents through autophagy and of extracellular components through endocytosis …

Microglia, the brain-resident immune cells, play an essential role in the upkeep of brain
homeostasis. They actively adapt into specific activation states based on cues from the …

The phospholipase D (PLD) family is comprised of enzymes bearing phospholipase activity
towards lipids or endo-and exonuclease activity towards nucleic acids. PLD3 is synthesized …

Summary Toll-like receptor 7 (TLR7) is essential for recognition of RNA viruses and initiation
of antiviral immunity. TLR7 contains two ligand-binding pockets that recognize different RNA …

Human 5′‐3′ exonuclease PLD3, a member of the phospholipase D family of enzymes,
has been validated as a therapeutic target for treating Alzheimer's disease. Here, we have …

Endolysosomal exonucleases PLD3 and PLD4 (phospholipases D3 and D4) are associated
with autoinflammatory and autoimmune diseases. We report structures of these enzymes …

Food additive amorphous silicon dioxide (SiO2) particles are manufactured by two different
methods—precipitated and fumed procedures—which can induce different physicochemical …

Herein, we report the development of a graphene-oxide-based (GO-based) fluorescent
bioassay for determining agrC gene transcription (mRNA) in methicillin-resistant …

Abstract Phospholipase D3 (PLD3) polymorphisms are linked to late-onset Alzheimer's
disease (LOAD). Being a lysosomal 5'-3'exonuclease, its neuronal substrates remained …

Protein AMPylation is a posttranslational modification with an emerging role in
neurodevelopment. In metazoans two highly conserved protein AMP-transferases together …