ALS genetics, mechanisms, and therapeutics: where are we now?
The scientific landscape surrounding amyotrophic lateral sclerosis (ALS) continues to shift
as the number of genes associated with the disease risk and pathogenesis, and the cellular …
as the number of genes associated with the disease risk and pathogenesis, and the cellular …
Amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis is characterised by the progressive loss of motor neurons in
the brain and spinal cord. This neurodegenerative syndrome shares pathobiological …
the brain and spinal cord. This neurodegenerative syndrome shares pathobiological …
Neurofilaments and neurofilament proteins in health and disease
Neurofilaments (NFs) are unique among tissue-specific classes of intermediate filaments
(IFs) in being heteropolymers composed of four subunits (NF-L [neurofilament light]; NF-M …
(IFs) in being heteropolymers composed of four subunits (NF-L [neurofilament light]; NF-M …
Amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease, is characterized
by the degeneration of both upper and lower motor neurons, which leads to muscle …
by the degeneration of both upper and lower motor neurons, which leads to muscle …
The genetics and neuropathology of amyotrophic lateral sclerosis
A Al-Chalabi, A Jones, C Troakes, A King… - Acta …, 2012 - Springer
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of motor neurons
leading to death from respiratory failure within about 3 years of symptom onset. A family …
leading to death from respiratory failure within about 3 years of symptom onset. A family …
Maternal plasma folate impacts differential DNA methylation in an epigenome-wide meta-analysis of newborns
BR Joubert, HT Den Dekker, JF Felix, J Bohlin… - Nature …, 2016 - nature.com
Folate is vital for fetal development. Periconceptional folic acid supplementation and food
fortification are recommended to prevent neural tube defects. Mechanisms whereby …
fortification are recommended to prevent neural tube defects. Mechanisms whereby …
Genetics of amyotrophic lateral sclerosis: an update
S Chen, P Sayana, X Zhang, W Le - Molecular neurodegeneration, 2013 - Springer
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder involving
both upper motor neurons (UMN) and lower motor neurons (LMN). Enormous research has …
both upper motor neurons (UMN) and lower motor neurons (LMN). Enormous research has …
Emerging mechanisms of molecular pathology in ALS
Amyotrophic lateral sclerosis (ALS) is a devastating degenerative disease characterized by
progressive loss of motor neurons in the motor cortex, brainstem, and spinal cord. Although …
progressive loss of motor neurons in the motor cortex, brainstem, and spinal cord. Although …
The neglected genes of ALS: cytoskeletal dynamics impact synaptic degeneration in ALS
MJ Castellanos-Montiel, M Chaineau… - Frontiers in Cellular …, 2020 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that selectively affects
motor neurons (MNs) of the cortex, brainstem, and spinal cord. Several genes have been …
motor neurons (MNs) of the cortex, brainstem, and spinal cord. Several genes have been …
The role of neurofilament aggregation in neurodegeneration: lessons from rare inherited neurological disorders
A Didonna, P Opal - Molecular neurodegeneration, 2019 - Springer
Many neurodegenerative disorders, including Parkinson's, Alzheimer's, and amyotrophic
lateral sclerosis, are well known to involve the accumulation of disease-specific proteins …
lateral sclerosis, are well known to involve the accumulation of disease-specific proteins …