Iron, an essential mineral in the body, is involved in numerous physiological processes,
making the maintenance of iron homeostasis crucial for overall health. Both iron overload …

The global diabetes epidemic and its complications are increasing, thereby posing a major
threat to public health. A comprehensive understanding of diabetes mellitus (DM) and its …

Recent findings have demonstrated that mitochondria can be transferred between cells to
control metabolic homeostasis. Although the mitochondria of brown adipocytes comprise a …

Ferroptosis is an iron-dependent cell death caused by impaired glutathione metabolism,
lipid peroxidation and mitochondrial failure. Emerging evidences report a role for ferroptosis …

Iron is an essential component in many biological processes in the human body. It is critical
for the visual phototransduction cascade in the retina. However, excess iron can be toxic …

G protein-coupled receptors (GPCRs) are a large family of membrane protein receptors, and
Takeda G protein-coupled receptor 5 (TGR5) is a member of this family. As a membrane …

Ferroptosis is characterized as a novel form of regulated cell death, which is initiated by the
lethal accumulation of lipid peroxidation catalyzed by cellular labile free iron. This iron …

Thermogenesis by uncoupling protein 1 (UCP1) is one of the primary mechanisms by which
brown adipose tissue (BAT) increases energy expenditure. UCP1 resides in the inner …

Programed cell death plays a key role in promoting human development and maintaining
homeostasis. Ferroptosis is a recently identified pattern of programmed cell death that is …

Friedreich's ataxia (FA) is a debilitating, multisystemic disease caused by the depletion of
frataxin (FXN), a mitochondrial iron-sulfur (Fe-S) cluster biogenesis factor. To understand the …