Matrix metalloproteinases: from molecular mechanisms to physiology, pathophysiology, and pharmacology
LGN de Almeida, H Thode, Y Eslambolchi… - Pharmacological …, 2022 - ASPET
The first matrix metalloproteinase (MMP) was discovered in 1962 from the tail of a tadpole by
its ability to degrade collagen. As their name suggests, matrix metalloproteinases are …
its ability to degrade collagen. As their name suggests, matrix metalloproteinases are …
Multifunctional intracellular matrix metalloproteinases: implications in disease
Matrix metalloproteinases (MMPs) are zinc‐dependent endopeptidases that were first
discovered as proteases, which target and cleave extracellular proteins. During the past 20 …
discovered as proteases, which target and cleave extracellular proteins. During the past 20 …
Biochemical and biological attributes of matrix metalloproteinases
N Cui, M Hu, RA Khalil - Progress in molecular biology and translational …, 2017 - Elsevier
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that are
involved in the degradation of various proteins in the extracellular matrix (ECM). Typically …
involved in the degradation of various proteins in the extracellular matrix (ECM). Typically …
[HTML][HTML] Matrix metalloproteinases participation in the metastatic process and their diagnostic and therapeutic applications in cancer
G Gonzalez-Avila, B Sommer… - Critical reviews in …, 2019 - Elsevier
Matrix metalloproteinases (MMPs) participate from the initial phases of cancer onset to the
settlement of a metastatic niche in a second organ. Their role in cancer progression is …
settlement of a metastatic niche in a second organ. Their role in cancer progression is …
The role of matrix metalloproteinases in the epithelial‐mesenchymal transition of hepatocellular carcinoma
C Scheau, IA Badarau, R Costache… - Analytical cellular …, 2019 - Wiley Online Library
The epithelial‐mesenchymal transition (EMT) is a transformation process mandatory for the
local and distant progression of many malignant tumors, including hepatocellular carcinoma …
local and distant progression of many malignant tumors, including hepatocellular carcinoma …
[HTML][HTML] Implications of MMP9 for blood brain barrier disruption and hemorrhagic transformation following ischemic stroke
Numerous studies have documented increases in matrix metalloproteinases (MMPs),
specifically MMP-9 levels following stroke, with such perturbations associated with …
specifically MMP-9 levels following stroke, with such perturbations associated with …
Matrix Metalloproteinases: A challenging paradigm of cancer management
Matrix metalloproteinases (MMPs) are members of zinc-dependent endopeptidases
implicated in a variety of physiological and pathological processes. Over the decades …
implicated in a variety of physiological and pathological processes. Over the decades …
Regulation of matrix metalloproteinase activity in health and disease
E Hadler‐Olsen, B Fadnes, I Sylte… - The FEBS …, 2011 - Wiley Online Library
The activity of matrix metalloproteinases (MMPs) is regulated at several levels, including
enzyme activation, inhibition, complex formation and compartmentalization. Regulation at …
enzyme activation, inhibition, complex formation and compartmentalization. Regulation at …
Diverse roles of matrix metalloproteinases and tissue inhibitors of metalloproteinases in neuroinflammation and cerebral ischemia
Regulation of the extracellular matrix by proteases and protease inhibitors is a fundamental
biological process for normal growth, development and repair in the CNS. Matrix …
biological process for normal growth, development and repair in the CNS. Matrix …
Matrix metalloproteinase-2 and myocardial oxidative stress injury: beyond the matrix
Abstract Matrix metalloproteinase (MMP)-2 belongs to a family of zinc-dependent proteases
which are best known for their ability to proteolyse extracellular matrix proteins throughout …
which are best known for their ability to proteolyse extracellular matrix proteins throughout …