[HTML][HTML] A three-ring circus: metabolism of the three proteogenic aromatic amino acids and their role in the health of plants and animals
A Parthasarathy, PJ Cross, RCJ Dobson… - Frontiers in molecular …, 2018 - frontiersin.org
Tyrosine, phenylalanine and tryptophan are the three aromatic amino acids (AAA) involved
in protein synthesis. These amino acids and their metabolism are linked to the synthesis of a …
in protein synthesis. These amino acids and their metabolism are linked to the synthesis of a …
Development of halogenase enzymes for use in synthesis
J Latham, E Brandenburger, SA Shepherd… - Chemical …, 2018 - ACS Publications
Nature has evolved halogenase enzymes to regioselectively halogenate a diverse range of
biosynthetic precursors, with the halogens introduced often having a profound effect on the …
biosynthetic precursors, with the halogens introduced often having a profound effect on the …
Bacterial terpenome
Covering: up to mid-2020 Terpenoids, also called isoprenoids, are the largest and most
structurally diverse family of natural products. Found in all domains of life, there are over 80 …
structurally diverse family of natural products. Found in all domains of life, there are over 80 …
[HTML][HTML] Mini review: Genome mining approaches for the identification of secondary metabolite biosynthetic gene clusters in Streptomyces
Streptomyces are a large and valuable resource of bioactive and complex secondary
metabolites, many of which have important clinical applications. With the advances in high …
metabolites, many of which have important clinical applications. With the advances in high …
Assembly-line enzymology for polyketide and nonribosomal peptide antibiotics: logic, machinery, and mechanisms
MA Fischbach, CT Walsh - Chemical reviews, 2006 - ACS Publications
Many thousands of small molecule natural products with interesting biological activities are
polyketides (PK), nonribosomal peptides (NRP), or hybrids thereof (ie, PK-NRP hybrids) …
polyketides (PK), nonribosomal peptides (NRP), or hybrids thereof (ie, PK-NRP hybrids) …
Natural product drug discovery in the genomic era: realities, conjectures, misconceptions, and opportunities
RH Baltz - Journal of Industrial Microbiology and Biotechnology, 2019 - academic.oup.com
Natural product discovery from microorganisms provided important sources for antibiotics,
anti-cancer agents, immune-modulators, anthelminthic agents, and insecticides during a …
anti-cancer agents, immune-modulators, anthelminthic agents, and insecticides during a …
Cytochromes P450 for natural product biosynthesis in Streptomyces: sequence, structure, and function
Covering: up to January 2017 Cytochrome P450 enzymes (P450s) are some of the most
exquisite and versatile biocatalysts found in nature. In addition to their well-known roles in …
exquisite and versatile biocatalysts found in nature. In addition to their well-known roles in …
[图书][B] Anticancer agents from natural products
GM Cragg, DGI Kingston, DJ Newman - 2005 - taylorfrancis.com
Plants, marine organisms, and microorganisms have evolved complex chemical defense
and signaling systems that are designed to protect them from predators and provide other …
and signaling systems that are designed to protect them from predators and provide other …
Polyketide and nonribosomal peptide antibiotics: modularity and versatility
CT Walsh - Science, 2004 - science.org
Polyketide (PK) and nonribosomal peptides (NRP), constructed on multimodular enzymatic
assembly lines, often attain the conformations that establish biological activity by cyclization …
assembly lines, often attain the conformations that establish biological activity by cyclization …