Liver fibrosis is the result of sustained chronic liver injury and inflammation leading to
hepatocyte cell death followed by the formation of fibrous scars, which is the hallmark of …

Abstract Background Cirsii Japonici Herba Carbonisata (Dajitan in Chinese) has been used
to treat liver disorders in Asian countries. Pectolinarigenin (PEC), an abundant constituent in …

Non-alcoholic fatty liver disease (NAFLD) is a global condition characterized by an
accumulation of lipids in the hepatocytes. NAFLD ranges from simple steatosis, a reversible …

Materials and Methods: Twenty-five ICR mice and 20 BALB/C mice were used where five
animals as control and the rest were randomly divided into four time points at 5, 10, 24 and …

Drug‐induced liver injury (DILI) is a frequent cause responsible for acute liver failure (ALF).
Acetaminophen (APAP) is a known hepatotoxin predictably causing intrinsic DILI. At high …

Aims Acetaminophen is the medication of choice when treating fever because of its limited
anti-inflammatory effects. However at overdose it can cause mitochondrial dysfunction and …

Background and Purpose Protective mechanisms of the endogenous cannabinoid system
against drug‐induced liver injury (DILI) are actively being investigated regarding the …

In order to provide timely treatment for organ damage initiated by therapeutic drugs or
exposure to environmental toxicants, we first need to identify markers that provide an early …

Drug-induced liver injury (DILI) has increased in recent years, leading to acute liver failure.
3, 3′, 5-triiodo-l-thyronine (T3) has been reported to exert a potent hepatoprotective effect …

Background: Acetaminophen (APAP), a common analgesic agent, is hepatotoxic in
overdose. N-acetylcysteine (NAC), as an APAP antidote, shows anaphylactic reactions and …