The oral administration of therapeutic peptides and proteins is favoured from a patient and
commercial point of view. In order to reach the systemic circulation after oral administration …

Since 1984, when paclitaxel was approved by the FDA for the treatment of advanced
ovarian carcinoma, taxanes have been widely used as microtubule-targeting antitumor …

P-glycoprotein (P-gp) is crucial in the active transport of various substrates with diverse
structures out of cells, resulting in poor intestinal permeation and limited bioavailability …

Lipid based formulations (LBF) provide well proven opportunities to enhance the oral
absorption of drugs and drug candidates that sit close to, or beyond, the boundaries of …

Lipid-based nanocarriers have gained much interest as carriers of drugs with poor oral
bioavailability because of their remarkable advantages like low toxicity, affordable scale-up …

d-α-Tocopheryl polyethylene glycol 1000 succinate (simply TPGS or Vitamin E TPGS) is
formed by the esterification of Vitamin E succinate with polyethylene glycol 1000. As novel …

Abstract P-glycoprotein (P-gp) is an ATP-dependent efflux pump encoded by the MDR1
gene in humans, known to mediate multidrug resistance of neoplastic cells to cancer …

Lipid-based drug delivery systems (LBDDS) are one of the most studied bioavailability
enhancement technologies and are utilized in a number of US Food and Drug …

The oral route of drug administration is most preferred due to its ease of use, low cost, and
high patient compliance. However, the oral uptake of many small molecule drugs and …

The development of drug resistance continues to be a dominant hindrance toward curative
cancer treatment. Overexpression of a wide-spectrum of ATP-dependent efflux pumps, and …