Given the increase in antibiotic-resistant bacteria, alongside the alarmingly low rate of newly
approved antibiotics for clinical usage, we are on the verge of not having effective treatments …

Inflammation is intimately involved at all stages of atherosclerosis and remains a substantial
residual cardiovascular risk factor in optimally treated patients. The proof of concept that …

Systems Toxicology is the integration of classical toxicology with quantitative analysis of
large networks of molecular and functional changes occurring across multiple levels of …

The elucidation of a compound's Mechanism of Action (MoA) is a challenging task in the
drug discovery process, but it is important in order to rationalise phenotypic findings and to …

Despite extensive study of the EGF receptor (EGFR) signaling network, the immediate
posttranslational changes that occur in response to growth factor stimulation remain poorly …

Dysregulation of signaling pathways in multiple sclerosis (MS) can be analyzed by
phosphoproteomics in peripheral blood mononuclear cells (PBMCs). We performed in vitro …

Current epidemics, such as AIDS or flu, and the emergence of new threatening pathogens,
such as the one causing the current coronavirus disease 2019 (COVID-19) pandemic …

Phosphorylation of serine, threonine and tyrosine plays significant roles in cellular signal
transduction and in modifying multiple protein functions. Phosphoproteins are coordinated …

Highlights•Proteomics is a valuable tool for biomarker and novel therapeutic target
discovery.•Omics tools are key methodologies designed to target specific biological …

Part 2 of the review “Back to the Future” is dedicated to the evolutionary role of the bio-
medicolegal sciences, reporting the historical profiles, the state of the art, and prospects for …