Encapsulation and compartmentalization are fundamental to the evolution of cellular life, but
they also pose a challenge: how to partition the molecules that perform biological functions …

Membrane proteins that function as transporters or receptors must communicate with both
sides of the lipid bilayer in which they sit. This long distance communication enables …

Motivation Proteins are dynamic entities that undergo conformational changes critical for
their functions. Understanding the communication pathways and information transfer within …

Lipid membrane interfaces are complex environments that host essential cellular processes
such as binding of proteins or drug molecules. A key open question is how water molecules …

In the last decade two-pore intracellular channels (TPCs) attracted the interest of
researchers, still some key questions remain open. Their importance for vacuolar (plants) …

The secretory (Sec) pathway is essential for protein translocation in Bacillus subtilis. In
contrast to signal peptides (SPs), the key components of the Sec pathway lack excessive …

DExD/H-box proteins are soluble enzymes that couple binding and hydrolysis of adenosine
triphosphate (ATP) with reactions involving RNA metabolism or bind and push newly …

The Sec protein secretion machinery includes proteins whose reaction coordinates involve
large-scale conformational changes. Dynamic hydrogen-bond networks can provide …

Disaggregation and microtubule-severing nanomachines from the AAA+ (ATPases
associated with various cellular activities) superfamily assemble into ring-shaped hexamers …

The bacterial FtsK motor harvests energy from ATP to translocate double-stranded DNA
during cell division. Here, we probe the molecular mechanisms underlying coordinated DNA …