[HTML][HTML] Therapeutic strategies for COVID-19: progress and lessons learned

G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …

Emerging aspects of cytokine storm in COVID-19: The role of proinflammatory cytokines and therapeutic prospects

R Dharra, AK Sharma, S Datta - Cytokine, 2023 - Elsevier
COVID-19 has claimed millions of lives during the last 3 years since initial cases were
reported in Wuhan, China, in 2019. Patients with COVID-19 suffer from severe pneumonia …

Signaling pathways in macrophages: molecular mechanisms and therapeutic targets

M Li, M Wang, Y Wen, H Zhang, GN Zhao, Q Gao - MedComm, 2023 - Wiley Online Library
Macrophages play diverse roles in development, homeostasis, and immunity. Accordingly,
the dysfunction of macrophages is involved in the occurrence and progression of various …

Recent progress and prospects for anti-cytokine therapy in preclinical and clinical acute lung injury

GP Fadanni, JB Calixto - Cytokine & Growth Factor Reviews, 2023 - Elsevier
Acute respiratory distress syndrome (ARDS) is a heterogeneous cause of respiratory failure
that has a rapid onset, a high mortality rate, and for which there is no effective …

[HTML][HTML] Unlocking therapeutic potential: Integration of drug repurposing and immunotherapy for various disease targeting

VA Pawar, A Tyagi, C Verma, KP Sharma… - American Journal of …, 2023 - ncbi.nlm.nih.gov
Drug repurposing, also known as drug repositioning, entails the application of pre-approved
or formerly assessed drugs having potentially functional therapeutic amalgams for curing …

Mechanistic insight into the protective and pathogenic immune-responses against SARS-CoV-2

PK Purbey, K Roy, S Gupta, MK Paul - Molecular Immunology, 2023 - Elsevier
COVID-19 is a severe respiratory illness that has emerged as a devasting health problem
worldwide. The disease outcome is heterogeneous, which is most likely dependent on the …

Anti-GM-CSF otilimab versus sarilumab or placebo in patients with rheumatoid arthritis and inadequate response to targeted therapies: a phase III randomised trial …

PC Taylor, ME Weinblatt, IB McInnes… - Annals of the …, 2023 - ard.bmj.com
Objectives To investigate the efficacy and safety of otilimab, an anti-granulocyte-
macrophage colony-stimulating factor antibody, in patients with active rheumatoid arthritis …

Anti-GM-CSF otilimab versus tofacitinib or placebo in patients with active rheumatoid arthritis and an inadequate response to conventional or biologic DMARDs: two …

RM Fleischmann, D van der Heijde, V Strand… - Annals of the …, 2023 - ard.bmj.com
Objectives To investigate the efficacy and safety of otilimab, an antigranulocyte-macrophage
colony-stimulating factor antibody, in patients with active rheumatoid arthritis. Methods Two …

Investigational pharmacological agents for the treatment of ARDS

K Aribindi, M Lim, S Lakshminrusimha… - Expert Opinion on …, 2024 - Taylor & Francis
ABSTRACT Introduction Acute Respiratory Distress Syndrome (ARDS) is a heterogeneous
form of lung injury with severe hypoxemia and bilateral infiltrates after an inciting event that …

Protective role of the HSP90 inhibitor, STA-9090, in lungs of SARS-CoV-2-infected Syrian golden hamsters

LGT Alves, M Baumgardt, C Langner… - BMJ Open …, 2024 - bmjopenrespres.bmj.com
Introduction The emergence of new SARS-CoV-2 variants, capable of escaping the humoral
immunity acquired by the available vaccines, together with waning immunity and vaccine …