[HTML][HTML] Selenium in bodily homeostasis: hypothalamus, hormones, and highways of communication

P Toh, JL Nicholson, AM Vetter, MJ Berry… - International journal of …, 2022 - mdpi.com
The ability of the body to maintain homeostasis requires constant communication between
the brain and peripheral tissues. Different organs produce signals, often in the form of …

[HTML][HTML] Apigeninidin-rich Sorghum bicolor (L. Moench) extracts suppress A549 cells proliferation and ameliorate toxicity of aflatoxin B1-mediated liver and kidney …

SE Owumi, AI Kazeem, B Wu, LO Ishokare… - Scientific reports, 2022 - nature.com
Sorghum bicolor plant has a high abundance of 3-deoxyanthocyanins, flavonoids and other
polyphenol compounds that have been shown to offer numerous health benefits …

Trace and essential elements as vital components to improve the performance of the male reproductive system: implications in cell signaling pathways

A Morabbi, M Karimian - Journal of Trace Elements in Medicine and …, 2024 - Elsevier
Successful male fertilization requires the main processes such as normal spermatogenesis,
sperm capacitation, hyperactivation, and acrosome reaction. The progress of these …

Caffeic acid mitigates aflatoxin B1‐mediated toxicity in the male rat reproductive system by modulating inflammatory and apoptotic responses, testicular function, and …

SE Owumi, CE Irozuru, UO Arunsi… - Journal of food …, 2022 - Wiley Online Library
Abstract Aflatoxin B1 (AFB1) is a toxic metabolite of public health concern. The present study
investigates the protective effects of caffeic acid (CA) against AFB1‐induced oxidative stress …

3-Indolepropionic acid upturned male reproductive function by reducing oxido-inflammatory responses and apoptosis along the hypothalamic-pituitary-gonadal axis of …

SE Owumi, MT Otunla, UO Arunsi, ES Najophe - Toxicology, 2021 - Elsevier
We examined the effect of 3-Indolepropionic acid (3-IPA), an antioxidant on the
organophosphorus pesticide chlorpyrifos (CPF)-induced reproductive toxicity in rats. The …

[HTML][HTML] Chitosan/selenium nanoparticles attenuate diclofenac sodium-induced testicular toxicity in male rats

SM El-Megharbel, FA Al-Salmi, S Al-Harthi, K Alsolami… - Crystals, 2021 - mdpi.com
The detrimental effect of diclofenac sodium (Diclo-Na) on male reproductive organs is
reported upon in this paper. Chitosan is a polysaccharide composed of various amounts of …

The protective effect of 3‐indolepropanoic acid on aflatoxin B1‐induced systemic perturbation of the liver and kidney function in rats

SE Owumi, UO Arunsi… - Fundamental & Clinical …, 2023 - Wiley Online Library
Abstract Aflatoxin B1 (AFB1) is known to derange the hepatorenal system by redox, DNA
adduct formation and apoptotic networks. Endogenous 3‐indole propionic acid (3‐IPA) is a …

Chlorogenic acid co‐administration abates tamoxifen‐mediated reproductive toxicities in male rats: an experimental approach

SE Owumi, RA Anaikor, UO Arunsi… - Journal of Food …, 2021 - Wiley Online Library
Reports over the years have demonstrated toxic side effect–including reproductive toxicity‐
of tamoxifen (TAM), a drug of choice in the management of primary breast cancer …

Ameliorating effect of rutin against diclofenac-induced cardiac injury in rats with underlying function of FABP3, MYL3, and ANP

A Dogra, D Kour, A Gour, M Bhardwaj… - Drug and Chemical …, 2023 - Taylor & Francis
Diclofenac is a widely prescribed anti-inflammatory drug having cardiovascular
complications as one of the main liabilities that restrict its therapeutic use. We aimed to …

Cefepime and diclofenac sodium combined treatment‐potentiated multiple organ injury: Role of oxidative damage and disrupted lipid metabolism

M Aboubakr, A Abdelkader, OA Habotta… - … of Biochemical and …, 2021 - Wiley Online Library
Concurrent exposure to antimicrobial and nonsteroidal anti‐inflammatory drugs (NSAIDs) is
usually inevitable in most infections and postsurgery. Consequently, the present study was …