Malaria killed over 600,000 people in 2022, a death toll that has not improved since 2015.
Additionally, parasites and mosquitoes resistant to existing interventions are spreading …

Malaria remains a global health burden with Plasmodium falciparum accounting for the
highest mortality and morbidity. Malaria in pregnancy can lead to the development of …

Converting cryo-electron microscopy (cryo-EM) data into high-quality structural models is a
challenging problem of outstanding importance. Current refinement methods often generate …

Polysaccharides are abundant natural polymers, which in nature are at times covalently
modified with peptides and proteins. Polysaccharide–protein or polysaccharide–peptide …

Placental malaria is caused by Plasmodium falciparum-infected erythrocytes (IEs) adhering
to chondroitin sulfate proteoglycans in placenta via VAR2CSA-type PfEMP1. Human …

Molecular similarities between embryonic and malignant cells can be exploited to target
tumors through specific signatures absent in healthy adult tissues. One such embryonic …

Chondroitin sulfate (CS) and dermatan sulfate (DS) are linear anionic polysaccharides that
are widely present on the cell surface and in the cell matrix and connective tissue. CS and …

Placental accumulation of Plasmodium falciparum infected erythrocytes results in maternal
anemia, low birth weight, and pregnancy loss. The parasite protein VAR2CSA facilitates the …

The enzyme N-acetylgalactosamine-4-sulfatase (Arylsulfatase B; ARSB) was originally
identified as a lysosomal enzyme which was deficient in Mucopolysaccharidosis VI (MPS VI; …

Plasmodium falciparum causes the most severe malaria in humans. Immunoglobulin M
(IgM) serves as the first line of humoral defense against infection and potently activates the …