Epigenetic modifications mainly includes nucleic modifications and histone modifications,
which play crucial role in biological processes, such as gene and microRNA expression …

In the field of medicinal chemistry, the precise installation of a trideuteromethyl group is
gaining ever‐increasing attention. Site‐selective incorporation of the deuterated “magic …

Neurons harbor high levels of single-strand DNA breaks (SSBs) that are targeted to
neuronal enhancers, but the source of this endogenous damage remains unclear. Using two …

Transfer RNAs (tRNAs) are abundant small non-coding RNAs that are crucially important for
decoding genetic information. Besides fulfilling canonical roles as adaptor molecules during …

The epigenetic modification 5-hydroxymethylcytosine (5hmC) plays a crucial role in the
regulation of gene expression. Although some methods have been developed to detect …

DNA cytosine methylation (5-methylcytosine, 5mC) is the most important epigenetic mark in
higher eukaryotes. 5mC in genomes is dynamically controlled by writers and erasers. DNA …

Multicellular organisms developed the concept of specialized cells that perform specific
functions. Examples are neurons and fibroblast to name just two out of more than 200 …

Methylation of the fifth position of cytosine (5mC) is an important epigenetic modification of
DNA. It has been shown that the oxidized derivatives of 5mC, namely 5 …

COPD, characterized by long-term poorly irreversible airway limitation and persistent
respiratory symptoms, has resulted in enormous challenges to human health worldwide …

The repertoire of nucleobase methylation in DNA and RNA, introduced by chemical agents
or enzymes, is large. Most methylation can be reversed either directly by restoration of the …