Genome-wide association studies (GWAS) have successfully identified many trait-
associated variants, but there is still much we do not know about the genetic basis of …

The vast majority of human mutations have minor allele frequencies under 1%, with the
plurality observed only once (that is,'singletons'). While Mendelian diseases are …

Natural populations often grow, shrink, and migrate over time. Such demographic processes
can affect genome-wide levels of genetic diversity. Additionally, genetic variation in …

Genomic data encode past evolutionary events and have the potential to reveal the strength,
rate and biological drivers of adaptation. However, joint estimation of adaptation rate (α) and …

The role of rare alleles in complex phenotypes has been hotly debated, but most rare variant
association tests (RVATs) do not account for the evolutionary forces that affect genetic …

The genetic component of complex disease risk in humans remains largely unexplained. A
corollary is that the allelic spectrum of genetic variants contributing to complex disease risk …

The vast majority of human mutations have minor allele frequencies (MAF) under 1%, with
the plurality observed only once (ie,“singletons”). While Mendelian diseases are …

Modern implementations of forward population genetic simulations are efficient and flexible,
enabling the exploration of complex models that may otherwise be intractable. Here we …

While it is well established that genetics can be a major contributor to population variation of
complex traits, the relative contributions of rare and common variants to phenotypic variation …

Although genome sequencing has become increasingly popular, the simulation of individual
genomes is still important. This is because sequencing a large number of individual …