Despite being the most frequently altered oncogenic protein in solid tumours, KRAS has
historically been considered 'undruggable'owing to a lack of pharmacologically targetable …

Single-cell technologies, particularly single-cell RNA sequencing (scRNA-seq) methods,
together with associated computational tools and the growing availability of public data …

A large body of evidence generated in the last two and a half years addresses the roles of T
cells in SARS-CoV-2 infection and following vaccination. Infection or vaccination induces …

Background Current UK vaccination policy is to offer future COVID-19 booster doses to
individuals at high risk of serious illness from COVID-19, but it is still uncertain which groups …

Neutralizing antibodies are known to have a crucial role in protecting against SARS-CoV-2
infection and have been suggested to be a useful correlate of protection for vaccine clinical …

Background Synthesising evidence on the long-term vaccine effectiveness of COVID-19
vaccines (BNT162b2 [Pfizer–BioNTech], mRNA-1273 [Moderna], ChAdOx1 nCoV-19 …

Neutralizing antibodies can block infection, clear pathogens, and are essential to provide
long-term immunity. Since the onset of the pandemic, SARS-CoV-2 neutralizing antibodies …

Importance Efficacy of 2 doses of the BNT162b2 COVID-19 vaccine (Pfizer-BioNTech)
against COVID-19 was high in pediatric trials conducted before the SARS-CoV-2 Omicron …

Importance Data about the association of COVID-19 vaccination and prior SARS-CoV-2
infection with risk of SARS-CoV-2 infection and severe COVID-19 outcomes may guide …

Background There is a paucity of data on vaccine-induced or infection-induced (hybrid or
natural) immunity against omicron (B. 1.1. 529) subvariant BA. 2, particularly in comparing …