The incidence of stroke and dementia are diverging across the world, rising for those in low-
and middle-income countries and falling in those in high-income countries. This suggests …

Gangliosides, sialylated glycosphingolipids, found on all vertebrate cells and tissues, are
major molecular determinants on the surfaces of vertebrate nerve cells. Composed of a …

For decades lysophosphatidylcholine (LPC, lysolecithin) has been used to induce
demyelination, without a clear understanding of its mechanisms. LPC is an endogenous …

Lipid rafts are small, dynamic membrane areas characterized by the clustering of selected
membrane lipids as the result of the spontaneous separation of glycolipids, sphingolipids …

Gangliosides play vital biological regulatory roles and are associated with neurological
system diseases, malignancies, and immune deficiencies. They have received extensive …

Imaging mass spectrometry (IMS) has become a powerful tool to characterize the spatial
distribution of biomolecules in thin tissue sections. In the case of matrix-assisted laser …

Recent advances in the understanding of basic pathological mechanisms in various
neurological diseases depend directly on the development of novel bioanalytical …

Matrix assisted laser desorption ionization (MALDI) imaging mass spectrometry (IMS) is
used to perform mass spectrometric analysis directly on biological samples providing visual …

Multiple sclerosis (MS) is an autoimmune disease that damages the myelin sheaths of nerve
cells in the central nervous system. An individual suffering from MS produces increased …

Sample preparation is key for optimal detection and visualization of analytes in Matrix-
assisted Laser Desorption/Ionization (MALDI) Imaging Mass Spectrometry (IMS) …