Ketamine, an N-methyl-d-aspartate receptor (NMDAR) antagonist first developed as an
anesthetic, has shown significant promise as a medication with rapid antidepressant …

The N-methyl-d-aspartate receptor (NMDAR) antagonist (R, S)-ketamine causes rapid onset
and sustained antidepressant actions in treatment-resistant patients with major depressive …

The spleen, an important tissue for the immune system, acts as a filter for blood within the
immune system. Accumulating evidence suggests that the spleen affects a number of brain …

Background Postpartum depression (PPD) is a prevalent public health issue. Although
ketamine has prophylactic effects on PPD in women undergoing cesarean section, the …

Highlights•Chronic stress, depression and inflammation have been consistently
linked.•Stress-induced inflammatory states can contribute to treatment resistance.•Ketamine …

Relapse is common in remitted patients with major depressive disorder (MDD). Arketamine,
an (R)-enantiomer of ketamine, has persistent prophylactic actions in an inflammatory model …

Abstract Classical psychedelics with 5-hydroxytryptamine-2A receptor (5-HT 2A R) agonism
have rapid antidepressant actions in patients with depression. However, there is an ongoing …

MicroRNAs (or miRNAs) are short, regulatory RNAs that act as post-transcriptional
repressors of gene expression. Recently, we reported that the nuclear factor of activated T …

Neuroinflammation plays a key role in the pathogenesis of major depressive disorder
(MDD), including treatment-resistant depression (TRD). Patients with TRD have higher …

Neurological disorders are the leading cause of disability and the second leading cause of
death worldwide. The increasing social and economic burdens of neurological disorders are …