General cognitive function is a prominent and relatively stable human trait that is associated
with many important life outcomes. We combine cognitive and genetic data from the …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with an estimated
heritability between 40 and 50%. DNA methylation patterns can serve as proxies of (past) …

Background People with neurodegenerative disorders show diverse clinical syndromes,
genetic heterogeneity, and distinct brain pathological changes, but studies report overlap …

Reduction in hippocampal and amygdala volume measured via structural magnetic
resonance imaging is an early marker of Alzheimer's disease (AD). Whether genetic risk …

We meta-analyze amyotrophic lateral sclerosis (ALS) genome-wide association study
(GWAS) data of European and Chinese populations (84,694 individuals). We find an …

Cross-ethnic genetic studies can leverage power from differences in disease epidemiology
and population-specific genetic architecture. In particular, the differences in linkage …

A wealth of empirical evidence is accumulating on the genetic mediation of brain structure
phenotypes. This comes from twin studies that assess heritability and genetic covariance …

White matter hyperintensities (WMH) are generally considered to be associated with
cerebral small vessel disease, especially, in older age. Although significant sex differences …

Abstract Interleukin 6 (IL-6) is a multifunctional cytokine with both pro-and anti-inflammatory
properties with a heritability estimate of up to 61%. The circulating levels of IL-6 in blood …

Background Previous findings for the genetic and environmental contributions to DNA
methylation variation were for limited age ranges only. We investigated the lifespan …