The methylation of histone H3 at lysine 36 (H3K36me) is essential for maintaining genomic
stability. Indeed, this methylation mark is essential for proper transcription, recombination …

Histone modifying enzymes play critical roles in many key cellular processes and are
appealing proteins for targeting by small molecules in disease. However, while the functions …

Abstract Histone Post-Translational Modifications (PTMs) play fundamental roles in
mediating DNA-related processes such as transcription, replication and repair. The histone …

Set2 co-transcriptionally methylates lysine 36 of histone H3 (H3K36), producing mono-, di-,
and trimethylation (H3K36me1/2/3). These modifications recruit or repel chromatin effector …

Precise positioning of the histone-H3 variant, CENP-A, ensures centromere stability and
faithful chromosomal segregation. Mislocalization of CENP-A to extra-centromeric loci …

Histone lysine methylation is a key epigenetic modification that regulates eukaryotic
transcription. Here, we comprehensively review the function and regulation of the histone …

Loss of transcription-coupled histone H3 lysine 36 trimethylation (H3K36me3) contributes to
shorter lifespans in eukaryotes. However, the molecular mechanism of the decline of …

AKT-phosphorylated IWS1 regulates alternative RNA splicing via a pathway that is active in
lung cancer. RNA-seq studies in lung adenocarcinoma cells lacking phosphorylated IWS1 …

The life cycle of HPV is tied to the differentiation status of its host cell, with productive
replication, late gene expression and virion production restricted to the uppermost layers of …

Histone posttranslational modifications control the organization and function of chromatin. In
particular, methylation of lysine 36 in histone H3 (H3K36me) has been shown to mediate …