Kidney-on-a-chip technology for drug-induced nephrotoxicity screening
Improved model systems to predict drug efficacy, interactions, and drug-induced kidney
injury (DIKI) are crucially needed in drug development. Organ-on-a-chip technology is a …
injury (DIKI) are crucially needed in drug development. Organ-on-a-chip technology is a …
Organ‐on‐a‐Chip Systems: microengineering to biomimic living systems
“Organ‐on‐a‐chip” systems integrate microengineering, microfluidic technologies, and
biomimetic principles to create key aspects of living organs faithfully, including critical …
biomimetic principles to create key aspects of living organs faithfully, including critical …
Immune-infiltrated kidney organoid-on-chip model for assessing T cell bispecific antibodies
T cell bispecific antibodies (TCBs) are the focus of intense development for cancer
immunotherapy. Recently, peptide-MHC (major histocompatibility complex)-targeted TCBs …
immunotherapy. Recently, peptide-MHC (major histocompatibility complex)-targeted TCBs …
[HTML][HTML] Bioprinting of 3D convoluted renal proximal tubules on perfusable chips
Three-dimensional models of kidney tissue that recapitulate human responses are needed
for drug screening, disease modeling, and, ultimately, kidney organ engineering. Here, we …
for drug screening, disease modeling, and, ultimately, kidney organ engineering. Here, we …
Nephrotoxicity and renal pathophysiology: a contemporary perspective
LMA Barnett, BS Cummings - Toxicological Sciences, 2018 - academic.oup.com
The kidney consists of numerous cell types organized into the nephron, which is the basic
functional unit of the kidney. Any stimuli that induce loss of these cells can induce kidney …
functional unit of the kidney. Any stimuli that induce loss of these cells can induce kidney …
[HTML][HTML] Effective exposure of chemicals in in vitro cell systems: A review of chemical distribution models
Nominal effect concentrations from in vitro toxicity assays may lead to inaccurate estimations
of in vivo toxic doses because the nominal concentration poorly reflects the concentration at …
of in vivo toxic doses because the nominal concentration poorly reflects the concentration at …
[HTML][HTML] 3D proximal tubule-on-chip model derived from kidney organoids with improved drug uptake
JO Aceves, S Heja, K Kobayashi, SS Robinson… - Scientific reports, 2022 - nature.com
Abstract Three-dimensional, organ-on-chip models that recapitulate kidney tissue are
needed for drug screening and disease modeling. Here, we report a method for creating a …
needed for drug screening and disease modeling. Here, we report a method for creating a …
Advances in predictive in vitro models of drug-induced nephrotoxicity
JYC Soo, J Jansen, R Masereeuw… - Nature Reviews …, 2018 - nature.com
In vitro screens for nephrotoxicity are currently poorly predictive of toxicity in humans.
Although the functional proteins that are expressed by nephron tubules and mediate drug …
Although the functional proteins that are expressed by nephron tubules and mediate drug …
[HTML][HTML] Role of oxidative stress in drug-induced kidney injury
K Hosohata - International journal of molecular sciences, 2016 - mdpi.com
The kidney plays a primary role in maintaining homeostasis and detoxification of numerous
hydrophilic xenobiotics as well as endogenous compounds. Because the kidney is exposed …
hydrophilic xenobiotics as well as endogenous compounds. Because the kidney is exposed …
Clinical use of the urine biomarker [TIMP-2]×[IGFBP7] for acute kidney injury risk assessment
Acute kidney injury (AKI) is a serious complication, commonly occurring in the critically ill
population, with devastating short-and long-term consequences. Despite standardization of …
population, with devastating short-and long-term consequences. Despite standardization of …