The epidemic of diabetes mellitus (DM) necessitates the development of novel therapeutic
and preventative strategies to attenuate complications of this debilitating disease. Diabetic …

Diabetes is now considered as a 'silent epidemic'that claims over four million lives every
year, and the disease knows no socioeconomic boundaries. Despite extensive efforts by the …

Objective: Extensive studies have shown that ERS may be implicated in the pathogenesis of
DCM. We explored the therapeutic effects of lncRNAH19 on DCM and its effect on ERS …

Nucleic acid-based therapeutics are currently developed at large scale for prevention and
management of cardiovascular diseases (CVDs), since:(i) genetic studies have highlighted …

To explore the underlying mechanism of lncRNA MALAT1 in the pathogenesis of diabetic
cardiomyopathy (DCM). DCM models were confirmed in db/db mice. MiRNAs in myocardium …

Autophagy is a highly conserved catabolic process and fundamental biological process in
eukaryotic cells. It recycles intracellular components to provide nutrients during starvation …

Diabetic cardiomyopathy is one of the main causes of heart failure and death in patients with
diabetes mellitus. Reactive oxygen species produced excessively in diabetes mellitus cause …

Metabolic imbalances and persistent hyperglycemia are widely recognized as driving forces
for augmented cytosolic and mitochondrial reactive oxygen species (ROS) in diabetes …

Aims Diabetic cardiomyopathy (DCM) is one of the major cardiovascular complications of
diabetes. However, the mechanism of DCM is not fully understood. Studies have confirmed …

Autophagy is a vital cell mechanism which plays an important role in many physiological
processes including clearing long-lived, accumulated and misfolded proteins, removing …