Almost all polymerase II transcripts undergo alternative pre-mRNA splicing. Here, we review
the functions of alternative splicing events that have been experimentally determined. The …

Prolactin has a rich mechanistic set of actions and signaling in order to elicit developmental
effects in mammals. Historically, prolactin has been appreciated as an endocrine peptide …

The epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases, also known
as ErbB or HER, plays crucial roles in the development of multicellular organisms. Mutations …

Ligands for ErbB1-4 receptor tyrosine kinases, such as epidermal growth factor (EGF) and
neuregulins, regulate brain development and function. Thus, abnormalities in their signaling …

Members of the ErbB subfamily of receptor tyrosine kinases are important regulators of
normal mammary gland physiology, and aberrations in their signaling have been associated …

Abstract Neuregulin 4 (Nrg4), an epidermal growth factor (EGF) family member, can bind to
and activate the ErbB4 receptor tyrosine kinase. Nrg4 has five different isoforms by …

The YAP1 gene encodes a potent new oncogene and stem cell factor. However, in some
cancers, the YAP1 gene plays a role of tumor suppressor. At present, the gene and its …

The ErbB receptor tyrosine kinase family has often been associated with increased growth of
breast epithelial cells, as well as malignant transformation and progression. In contrast …

The role of HER4 in breast cancer is controversial and its role in relation to trastuzumab
resistance remains unclear. We showed that trastuzumab treatment and its acquired …

Endocytosis and subsequent lysosomal degradation serve as a well characterized
mechanism to fine-tune and down-regulate EGFR signaling. However, other members of the …