Chronic stress increases metastasis via neutrophil-mediated changes to the microenvironment

XY He, Y Gao, D Ng, E Michalopoulou, S George… - Cancer cell, 2024 - cell.com
Chronic stress is associated with increased risk of metastasis and poor survival in cancer
patients, yet the reasons are unclear. We show that chronic stress increases lung metastasis …

Using mice to model human disease: understanding the roles of baseline housing-induced and experimentally imposed stresses in animal welfare and experimental …

BL Hylander, EA Repasky, S Sexton - Animals, 2022 - mdpi.com
Simple Summary Scientific research into the causes, progression, and treatment of disease
is dependent on the use of animal models. However, many scientists say that they cannot …

Multilevel assessment of stent-induced inflammation in the adjacent vascular tissue

K Kapnisis, A Stylianou, D Kokkinidou… - ACS Biomaterials …, 2023 - ACS Publications
A recent US Food and Drug Administration report presented the currently available scientific
information related to biological response to metal implants. In this work, a multilevel …

Neutrophil-to-lymphocyte ratio: a biomarker to monitor the immune status of astronauts

AM Paul, SD Mhatre, E Cekanaviciute… - Frontiers in …, 2020 - frontiersin.org
A comprehensive understanding of spaceflight factors involved in immune dysfunction and
the evaluation of biomarkers to assess in-flight astronaut health are essential goals for …

Welfare assessment in shelter dogs by using physiological and immunological parameters

C Righi, L Menchetti, R Orlandi, L Moscati, S Mancini… - Animals, 2019 - mdpi.com
Simple Summary In “no-kill policy” countries, many dogs live in shelters. Several social,
environmental, and management challenges can put the welfare of shelter dogs at risk …

Copper Intoxication in South American Camelids—Review of the Literature and First Report of a Case in a Vicuña (Vicugna vicugna)

H Marahrens, K von Dörnberg, V Molnár… - … Trace Element Research, 2024 - Springer
Copper (Cu), an essential trace element in the metabolism of mammals, plays a central role
in various metabolic processes. However, overdosing can lead to severe symptoms and …

Health Assessments of Koalas after Wildfire: A Temporal Comparison of Rehabilitated and Non-Rescued Resident Individuals

MR Lane, A Lowe, J Vukcevic, RG Clark, G Madani… - Animals, 2023 - mdpi.com
Simple Summary Bushfires are a regular occurrence in the Australian landscape. The
2019/20 megafires were unprecedented in intensity and scale, impacting many native …

Increased Neutrophil Percentage and Neutrophil–T Cell Ratio Precedes Clinical Onset of Experimental Cerebral Malaria

L Freire-Antunes, U Ornellas-Garcia… - International Journal of …, 2023 - mdpi.com
Newly emerging data suggest that several neutrophil defense mechanisms may play a role
in both aggravating and protecting against malaria. These exciting findings suggest that the …

Lipopolysaccharide exacerbates chronic restraint stress-induced neurobehavioral deficits: Mechanisms by redox imbalance, ASK1-related apoptosis, autophagic …

M Kwatra, S Ahmed, VK Gangipangi, SR Panda… - Journal of Psychiatric …, 2021 - Elsevier
Major depressive disorder (MDD) is the foremost leading psychiatric illness prevailing
around the globe. It usually exists along with anxiety and other clinical conditions …

The effect of group size, age and handling frequency on inter-male aggression in CD 1 mice

P Jirkof, N Bratcher, L Medina, D Strasburg, P Ebert… - Scientific reports, 2020 - nature.com
Aggression in male mice often leads to injury and death, making social housing difficult. We
tested whether (1) small group size,(2) early age of allocation to a group decreases …