Alzheimer's disease (AD) is a neurodegenerative disorder, most cases of which lack a clear
causative event. This has made the disease difficult to characterize and, thus, diagnose …

Abstract Alzheimer's disease (AD), the most common form of dementia, is characterized by
the accumulation of amyloid β (Aβ) and hyperphosphorylated tau protein aggregates …

Neuroinflammation and mitochondrial dysfunction are common features of chronic
neurodegenerative diseases of the central nervous system. Both conditions can lead to …

To match the metabolic demands of the brain, mechanisms have evolved to couple neuronal
activity to vasodilation, thus increasing local cerebral blood flow and delivery of oxygen and …

Alzheimer's disease (AD) is the most common neurodegenerative disorder that affects the
elderly. The increase of lifeexpectancy is transforming AD into a major health-care problem …

Tumor necrosis factor α (TNF-α) plays a central role in the pathophysiology of Alzheimer's
disease (AD). Food and Drug Administration–approved biologic TNF-α inhibitors are thus a …

Abstract Tumor Necrosis Factor-alpha (TNF-α) is a prototypic pro-inflammatory cytokine
involved in the innate immune response. TNF-α ligation and downstream signaling with one …

Neurodegenerative diseases are hereditary or sporadic conditions that result in the
progressive loss of the structure and function of neurons as well as neuronal death …

Alzheimer's disease (AD) is the most prominent neurodegenerative disorder in the aging
population. It is characterized by cognitive decline, gradual neurodegeneration, and the …

Oxidative stress has been proposed to be an important factor in the pathogenesis of
Alzheimer's disease (AD) and contributed to β-amyloid (A β) generation. Interaction between …