[HTML][HTML] Establishing neuronal diversity in the spinal cord: a time and a place
The vertebrate spinal cord comprises multiple functionally distinct neuronal cell types
arranged in characteristic positions. During development, these different types of neurons …
arranged in characteristic positions. During development, these different types of neurons …
PRC2 is high maintenance
As the process that silences gene expression ensues during development, the stage is set
for the activity of Polycomb-repressive complex 2 (PRC2) to maintain these repressed gene …
for the activity of Polycomb-repressive complex 2 (PRC2) to maintain these repressed gene …
[HTML][HTML] Polycomb repressive complex 1 generates discrete compacted domains that change during differentiation
Master regulatory genes require stable silencing by the polycomb group (PcG) to prevent
misexpression during differentiation and development. Some PcG proteins covalently modify …
misexpression during differentiation and development. Some PcG proteins covalently modify …
Motor neurons and the generation of spinal motor neuron diversity
N Stifani - Frontiers in cellular neuroscience, 2014 - frontiersin.org
Motor neurons (MNs) are neuronal cells located in the central nervous system (CNS)
controlling a variety of downstream targets. This function infers the existence of MN subtypes …
controlling a variety of downstream targets. This function infers the existence of MN subtypes …
Retinoic acid receptors: from molecular mechanisms to cancer therapy
Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …
Combinatorial analysis of developmental cues efficiently converts human pluripotent stem cells into multiple neuronal subtypes
Y Maury, J Côme, RA Piskorowski… - Nature …, 2015 - nature.com
Abstract Specification of cell identity during development depends on exposure of cells to
sequences of extrinsic cues delivered at precise times and concentrations. Identification of …
sequences of extrinsic cues delivered at precise times and concentrations. Identification of …
CRISPR and biochemical screens identify MAZ as a cofactor in CTCF-mediated insulation at Hox clusters
CCCTC-binding factor (CTCF) is critical to three-dimensional genome organization. Upon
differentiation, CTCF insulates active and repressed genes within Hox gene clusters. We …
differentiation, CTCF insulates active and repressed genes within Hox gene clusters. We …
CTCF establishes discrete functional chromatin domains at the Hox clusters during differentiation
Polycomb and Trithorax group proteins encode the epigenetic memory of cellular positional
identity by establishing inheritable domains of repressive and active chromatin within the …
identity by establishing inheritable domains of repressive and active chromatin within the …
Neuromesodermal progenitors and the making of the spinal cord
D Henrique, E Abranches, L Verrier… - Development, 2015 - journals.biologists.com
Neuromesodermal progenitors (NMps) contribute to both the elongating spinal cord and the
adjacent paraxial mesoderm. It has been assumed that these cells arise as a result of …
adjacent paraxial mesoderm. It has been assumed that these cells arise as a result of …
In Vitro Generation of Neuromesodermal Progenitors Reveals Distinct Roles for Wnt Signalling in the Specification of Spinal Cord and Paraxial Mesoderm Identity
Cells of the spinal cord and somites arise from shared, dual-fated precursors, located
towards the posterior of the elongating embryo. Here we show that these neuromesodermal …
towards the posterior of the elongating embryo. Here we show that these neuromesodermal …